» Articles » PMID: 25731670

MiR-630 Overexpression in Hepatocellular Carcinoma Tissues is Positively Correlated with Alpha-fetoprotein

Overview
Journal Med Sci Monit
Date 2015 Mar 4
PMID 25731670
Citations 12
Authors
Affiliations
Soon will be listed here.
Abstract

Background: MicroRNA-630 (miR-630) has been shown to be involved in various human malignancies. However, its role in hepatocellular carcinoma (HCC) remains unknown.

Material And Methods: TaqMan qRT-PCR assay was performed to detect the expression of miR-630 in 42 pairs of HCC tissues and corresponding noncancerous hepatocellular tissues, and its correlations with clinicopathologic features and serum alpha-fetoprotein (AFP) level of patients were analyzed.

Results: The present study found that miR-630 expression was significantly increased in HCC tissues and cells compared with their normal counterparts. miR-630 expression level did not significantly chang at stage I but was markedly increased at advanced TNM stage (stage II~III). In addition, the increased expression of miR-630 in tissues of HCC appeared in patients who exhibited elevated serum levels of AFP (>25 ng/ml), but not in those with normal AFP levels (≤25 ng/ml). The miR-630 expression in carcinoma tissues revealed a positive correlation with the levels of serum alpha-fetoprotein (AFP; R2=0.768).

Conclusions: These results suggest that miR-630 is associated with tumor progression of hepatocellular carcinoma and may be a potential prognosis indicator.

Citing Articles

MiR-630 Promotes Radioresistance by Induction of Anti-Apoptotic Effect via Nrf2-GPX2 Molecular Axis in Head-Neck Cancer.

You G, Cheng A, Shen E, Fan K, Huang Y, Huang Y Cells. 2023; 12(24).

PMID: 38132173 PMC: 10741482. DOI: 10.3390/cells12242853.


In silico analysis and experimental validation shows negative correlation between miR-1183 and cell cycle progression gene 1 expression in colorectal cancer.

Fatima S, Nasim M, Malik A, Rehman S, Waris S, Rauf M PLoS One. 2023; 18(8):e0289082.

PMID: 37540697 PMC: 10403070. DOI: 10.1371/journal.pone.0289082.


The importance of miRNA-630 in human diseases with an especial focus on cancers.

Kadkhoda S, Ghafouri-Fard S Cancer Cell Int. 2022; 22(1):105.

PMID: 35248081 PMC: 8897855. DOI: 10.1186/s12935-022-02531-z.


FOXM1 and Cancer: Faulty Cellular Signaling Derails Homeostasis.

Kalathil D, John S, Nair A Front Oncol. 2021; 10:626836.

PMID: 33680951 PMC: 7927600. DOI: 10.3389/fonc.2020.626836.


MicroRNA-98-5p Inhibits Tumorigenesis of Hepatitis B Virus-Related Hepatocellular Carcinoma by Targeting NF-κB-Inducing Kinase.

Fei X, Zhang P, Pan Y, Liu Y Yonsei Med J. 2020; 61(6):460-470.

PMID: 32469170 PMC: 7256008. DOI: 10.3349/ymj.2020.61.6.460.


References
1.
Morishita A, Masaki T . miRNA in hepatocellular carcinoma. Hepatol Res. 2014; 45(2):128-41. DOI: 10.1111/hepr.12386. View

2.
Li C, Zhao H, Zhao J, Li Z, Huang Z, Zhang Y . Prognosis of patients with hepatocellular carcinoma and hypersplenism after surgery: a single-center experience from the People's Republic of China. Onco Targets Ther. 2014; 7:957-64. PMC: 4061180. DOI: 10.2147/OTT.S64921. View

3.
Elzouki A, Elkhider H, Yacout K, Al Muzrakchi A, Al-Thani S, Ismail O . Metastatic hepatocellular carcinoma to parotid glands. Am J Case Rep. 2014; 15:343-7. PMC: 4144943. DOI: 10.12659/AJCR.890661. View

4.
Wang L, Yao M, Dong Z, Zhang Y, Yao D . Circulating specific biomarkers in diagnosis of hepatocellular carcinoma and its metastasis monitoring. Tumour Biol. 2013; 35(1):9-20. PMC: 3907675. DOI: 10.1007/s13277-013-1141-0. View

5.
Nomura F, Ohnishi K, Tanabe Y . Clinical features and prognosis of hepatocellular carcinoma with reference to serum alpha-fetoprotein levels. Analysis of 606 patients. Cancer. 1989; 64(8):1700-7. DOI: 10.1002/1097-0142(19891015)64:8<1700::aid-cncr2820640824>3.0.co;2-z. View