An Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones and Thiones Catalyzed by a Novel Brønsted Acidic Ionic Liquid Under Solvent-free Conditions

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2015 Mar 3

PMID 25730389

Citations 12

Authors

Yonghong Zhang

Bin Wang

Xiaomei Zhang

Jianbin Huang

Chenjiang Liu

Affiliations

Soon will be listed here.

Abstract

We report here an efficient and green method for Biginelli condensation reaction of aldehydes, β-ketoesters and urea or thiourea catalyzed by Brønsted acidic ionic liquid [Btto][p-TSA] under solvent-free conditions. Compared to the classical Biginelli reaction conditions, the present method has the advantages of giving good yields, short reaction times, near room temperature conditions and the avoidance of the use of organic solvents and metal catalyst.

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