Screening Cranial Imaging at Multiple Time Points Improves Cystic Periventricular Leukomalacia Detection

Overview

Journal Am J Perinatol

Specialty Gynecology & Obstetrics

Date 2015 Mar 3

PMID 25730135

Citations 13

Authors

Subrata Sarkar

Seetha Shankaran

Abbot R Laptook

Beena G Sood

Barbara Do

Barbara J Stoll

Krisa P Van Meurs

Edward F Bell

Abhik Das

John Barks

Affiliations

Soon will be listed here.

Abstract

Objective: The aim of this study is to determine whether the cystic periventricular leukomalacia (cPVL) detection rate differs between imaging studies performed at different time points.

Design: We retrospectively reviewed the prospectively collected data of 31,708 infants from the NICHD Neonatal Research Network. Inclusion criteria were infants < 1,000 g birth weight or < 29 weeks' gestational age who had cranial imaging performed using both early criterion (cranial ultrasound [CUS] < 28 days chronological age) and late criterion (CUS, magnetic resonance imaging, or computed tomography closest to 36 weeks postmenstrual age [PMA]). We compared the frequency of cPVL diagnosed by early and late criteria.

Results: About 664 (5.2%) of the 12,739 infants who met inclusion criteria had cPVL using either early or late criteria; 569 using the late criterion, 250 using the early criterion, and 155 patients at both times. About 95 (14.3%) of 664 cPVL cases seen on early imaging were no longer visible on repeat screening closest to 36 weeks PMA. Such disappearance of cPVL was more common in infants < 26 weeks' gestation versus infants of 26 to 28 weeks' gestation (18.5 vs. 11.5%; p = 0.013).

Conclusions: Cranial imaging at both < 28 days chronological age and closest to 36 weeks PMA improves cPVL detection, especially for more premature infants.

Citing Articles

Quantitative Evaluation of White Matter Injury by Cranial Ultrasound to Detect the Effects of Parenteral Nutrition in Preterm Babies: An Observational Study.

Laccetta G, De Nardo M, Cellitti R, Di Chiara M, Tagliabracci M, Parisi P J Imaging. 2024; 10(9).

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Quantitative ultrasonographic examination of cerebral white matter by pixel brightness intensity as marker of middle-term neurodevelopment: a prospective observational study.

Laccetta G, Di Chiara M, De Nardo M, Tagliabracci M, Travaglia E, De Santis B Sci Rep. 2023; 13(1):16816.

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White matter injury detection based on preterm infant cranial ultrasound images.

Zhu J, Yao S, Yao Z, Yu J, Qian Z, Chen P Front Pediatr. 2023; 11:1144952.

PMID: 37152321 PMC: 10157025. DOI: 10.3389/fped.2023.1144952.

Application of brain ultrasound in premature infants with brain injury.

Liu L Front Neurol. 2023; 14:1095280.

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Ultrasound imaging of preterm brain injury: fundamentals and updates.

Hwang M, Tierradentro-Garcia L, Hussaini S, Cajigas-Loyola S, Kaplan S, Otero H Pediatr Radiol. 2021; 52(4):817-836.

PMID: 34648071 DOI: 10.1007/s00247-021-05191-9.

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