Use of Phosphorodithioate-based Compounds As Hydrogen Sulfide Donors

Overview

Journal Methods Enzymol

Specialty Biochemistry

Date 2015 Mar 2

PMID 25725520

Citations 6

Authors

Chung-Min Park

Ming Xian

Affiliations

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Abstract

Synthetic hydrogen sulfide (H2S) donors are useful research tools as well as potential therapeutic agents. In this chapter, we report the detailed protocols for the synthesis and evaluation of a series of phosphorodithioate-based H2S donors. Fluorescence assays were used to determine H2S release from the donors in both aqueous buffers and in cultured cells. These donors were found to be slow-release donors, much like the well-known GYY4137. These donors also showed some protective effects against hydrogen peroxide (H2O2)-induced oxidative damage in myocytes.

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