Survivin-specific Small Interfering RNAs Enhance Sensitivity of Glioma U-87MG Cells to Paclitaxel by Promoting Apoptosis

Overview

Journal Neural Regen Res

Date 2015 Feb 28

PMID 25722690

Citations 1

Authors

Yunliang Xie

Yanbo Liu

Weigao Shen

Bo Zhang

Qun Liu

Affiliations

Soon will be listed here.

Abstract

A survivin siRNA expression vector was transfected into glioma U-87MG cells and these cells were then treated with paclitaxel. The results showed that survivin-specific siRNA combined with paclitaxel treatment synergistically inhibited glioma U-87MG cell proliferation and promoted apoptosis. This treatment also inhibited the expression of the cell cycle regulatory proteins, survivin, cyclinD1, c-Myc and CDK4 and enhanced the sensitivity of U-87MG cells to paclitaxel.

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PMID: 39075190 PMC: 11286837. DOI: 10.1038/s41598-024-65018-z.

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