The Human Placental Methylome

Overview

Journal Cold Spring Harb Perspect Med

Specialty General Medicine

Date 2015 Feb 28

PMID 25722473

Citations 49

Authors

Wendy P Robinson

E Magda Price

Affiliations

Soon will be listed here.

Abstract

This review provides an overview of the unique features of DNA methylation in the human placenta. We discuss the importance of understanding placental development, structure, and function in the interpretation of DNA methylation data. Examples are given of how DNA methylation is important in regulating placental-specific gene expression, including monoallelic expression and X-chromosome inactivation in the placenta. We also discuss studies of global DNA methylation changes in the context of placental pathology and environmental exposures.

Citing Articles

Breaking rules: the complex relationship between DNA methylation and X-chromosome inactivation in the human placenta.

Inkster A, Matthews A, Phung T, Plaisier S, Wilson M, Brown C Biol Sex Differ. 2025; 16(1):18.

PMID: 40038810 PMC: 11877730. DOI: 10.1186/s13293-025-00696-6.

The role of DNA methylation in placental development and its implications for preeclampsia.

Meng Y, Meng Y, Li L, Li Y, He J, Shan Y Front Cell Dev Biol. 2024; 12:1494072.

PMID: 39691449 PMC: 11649665. DOI: 10.3389/fcell.2024.1494072.

Prenatal chemical exposures and the methylome: current evidence and opportunities for environmental epigenetics.

Bozack A, Trasande L Epigenomics. 2024; 16(23-24):1443-1451.

PMID: 39539208 PMC: 11622816. DOI: 10.1080/17501911.2024.2426441.

DNA Methylation Signatures in Paired Placenta and Umbilical Cord Samples: Relationship with Maternal Pregestational Body Mass Index and Offspring Metabolic Outcomes.

Gomez-Vilarrubla A, Mas-Pares B, Carreras-Badosa G, Bonmati-Santane A, Martinez-Calcerrada J, Niubo-Pallas M Biomedicines. 2024; 12(2).

PMID: 38397903 PMC: 10886657. DOI: 10.3390/biomedicines12020301.

Conserved and divergent features of trophoblast stem cells.

Sah N, Soncin F J Mol Endocrinol. 2024; 72(4).

PMID: 38276878 PMC: 11008758. DOI: 10.1530/JME-23-0131.

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