Vascular Function, Cerebral Cortical Thickness, and Cognitive Performance in Middle-aged Hispanic and Non-Hispanic Caucasian Adults

Overview

Journal J Clin Hypertens (Greenwich)

Specialty Cardiology & Vascular Diseases

Date 2015 Feb 28

PMID 25720950

Citations 10

Authors

Evan P Pasha

Sonya S Kaur

Mitzi M Gonzales

Daniel R Machin

Kennon Kasischke

Hirofumi Tanaka

Andreana P Haley

Affiliations

Soon will be listed here.

Abstract

Hispanics are at increased risk for acquiring cardiovascular risk factors that contribute to cognitive dysfunction. To compare indices of vascular health with measures of cerebral gray matter integrity, 60 middle-aged Hispanic and non-Hispanic Caucasian participants were matched across age, sex, years of education, and mental status. Arterial stiffness was characterized by β-stiffness index and carotid-femoral pulse wave velocity, and magnetic resonance imaging estimated cortical thickness in a priori regions of interest known to be susceptible to vascular risk factors. Measures of arterial stiffness were significantly higher in Hispanics than in non-Hispanic Caucasians. Hispanics exhibited thinner left inferior frontal gyrus (LIFG) cortical thickness (P=.04) with concurrently lower language (P=.02), memory (P=.03), and attention-executive functioning (P=.02). These results suggest that compromised vascular health may occur simultaneously with cortical thinning of the LIFG as an early neuropathological alteration in Hispanics.

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References

de la Torre J . Cardiovascular risk factors promote brain hypoperfusion leading to cognitive decline and dementia. Cardiovasc Psychiatry Neurol. 2012; 2012:367516. PMC: 3518077. DOI: 10.1155/2012/367516. View

Thompson-Schill S, Jonides J, Marshuetz C, Smith E, DEsposito M, Kan I . Effects of frontal lobe damage on interference effects in working memory. Cogn Affect Behav Neurosci. 2002; 2(2):109-20. DOI: 10.3758/cabn.2.2.109. View

Du A, Schuff N, Kramer J, Rosen H, Gorno-Tempini M, Rankin K . Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia. Brain. 2007; 130(Pt 4):1159-66. PMC: 1853284. DOI: 10.1093/brain/awm016. View

Farrer L, Cupples L, Haines J, Hyman B, Kukull W, Mayeux R . Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA. 1997; 278(16):1349-56. View

Yasmin , Brown M . Similarities and differences between augmentation index and pulse wave velocity in the assessment of arterial stiffness. QJM. 2000; 92(10):595-600. DOI: 10.1093/qjmed/92.10.595. View

Kennedy K, Raz N . Pattern of normal age-related regional differences in white matter microstructure is modified by vascular risk. Brain Res. 2009; 1297:41-56. PMC: 2758325. DOI: 10.1016/j.brainres.2009.08.058. View

Solfrizzi V, Panza F, Colacicco A, DIntrono A, Capurso C, Torres F . Vascular risk factors, incidence of MCI, and rates of progression to dementia. Neurology. 2004; 63(10):1882-91. DOI: 10.1212/01.wnl.0000144281.38555.e3. View

Arvanitakis Z, Leurgans S, Barnes L, Bennett D, Schneider J . Microinfarct pathology, dementia, and cognitive systems. Stroke. 2011; 42(3):722-7. PMC: 3042494. DOI: 10.1161/STROKEAHA.110.595082. View

Fischl B, Dale A . Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci U S A. 2000; 97(20):11050-5. PMC: 27146. DOI: 10.1073/pnas.200033797. View

10.

Crimmins E, Kim J, Alley D, Karlamangla A, Seeman T . Hispanic paradox in biological risk profiles. Am J Public Health. 2007; 97(7):1305-10. PMC: 1913070. DOI: 10.2105/AJPH.2006.091892. View

11.

Vermeer S, Prins N, den Heijer T, Hofman A, Koudstaal P, Breteler M . Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med. 2003; 348(13):1215-22. DOI: 10.1056/NEJMoa022066. View

12.

Tanaka H, Dinenno F, Monahan K, Clevenger C, DeSouza C, Seals D . Aging, habitual exercise, and dynamic arterial compliance. Circulation. 2000; 102(11):1270-5. DOI: 10.1161/01.cir.102.11.1270. View

13.

Leritz E, Salat D, Williams V, Schnyer D, Rudolph J, Lipsitz L . Thickness of the human cerebral cortex is associated with metrics of cerebrovascular health in a normative sample of community dwelling older adults. Neuroimage. 2010; 54(4):2659-71. PMC: 3026290. DOI: 10.1016/j.neuroimage.2010.10.050. View

14.

Okamoto Y, Yamamoto T, Kalaria R, Senzaki H, Maki T, Hase Y . Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts. Acta Neuropathol. 2011; 123(3):381-94. PMC: 3282897. DOI: 10.1007/s00401-011-0925-9. View

15.

DEsposito M, Kan I . Effects of repetition and competition on activity in left prefrontal cortex during word generation. Neuron. 1999; 23(3):513-22. DOI: 10.1016/s0896-6273(00)80804-1. View

16.

Haley A, Forman D, Poppas A, Hoth K, Gunstad J, Jefferson A . Carotid artery intima-media thickness and cognition in cardiovascular disease. Int J Cardiol. 2007; 121(2):148-54. PMC: 2042538. DOI: 10.1016/j.ijcard.2006.10.032. View

17.

Clark C, DeCarli C, Mungas D, Chui H, Higdon R, Nunez J . Earlier onset of Alzheimer disease symptoms in latino individuals compared with anglo individuals. Arch Neurol. 2005; 62(5):774-8. DOI: 10.1001/archneur.62.5.774. View

18.

. 2013 Alzheimer's disease facts and figures. Alzheimers Dement. 2013; 9(2):208-45. DOI: 10.1016/j.jalz.2013.02.003. View

19.

Kovari E, Gold G, Herrmann F, Canuto A, Hof P, Bouras C . Cortical microinfarcts and demyelination affect cognition in cases at high risk for dementia. Neurology. 2007; 68(12):927-31. DOI: 10.1212/01.wnl.0000257094.10655.9a. View

20.

Kume K, Hanyu H, Sato T, Hirao K, Shimizu S, Kanetaka H . Vascular risk factors are associated with faster decline of Alzheimer disease: a longitudinal SPECT study. J Neurol. 2011; 258(7):1295-303. DOI: 10.1007/s00415-011-5927-y. View