Exposure Reconstruction and Risk Analysis for Six Semiconductor Workers With Lymphohematopoietic Cancers

Overview

Journal J Occup Environ Med

Specialty Environmental Health

Date 2015 Feb 27

PMID 25719533

Citations 3

Authors

Rachael M Jones

Linda Dell

Craig Torres

Catherine E Simmons

James Poole

Fred W Boelter

Paul Harper

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate whether workplace exposures to recognized lymphohematopoietic carcinogens were possibly related to cancers in six semiconductor-manufacturing workers.

Methods: A job-exposure matrix was developed for chemical and physical process agents and anticipated by-products. Potential cumulative occupational exposures of the six cases were reconstructed. The role of workplace exposures in cancer was evaluated through quantitative risk assessment and by comparison with epidemiological literature.

Results: Two workers were potentially exposed to agents capable of causing their diagnosed cancers. Reconstructed exposures were similar to levels in outdoor environments and lower than exposures associated with increased risks in epidemiological studies. Cancer risks were estimated to be less than 1 in 10,000 persons.

Conclusions: The development of cancer among the six workers was unlikely to be explained by occupational exposures to recognized lymphohematopoietic carcinogens.

Citing Articles

Biological Assessment of Potential Exposure to Occupational Substances in Current Semiconductor Workers with at Least 5 Years of Employment.

Kim K, Sung H, Jang J, Kang C, Lee K, Park S Int J Environ Res Public Health. 2022; 19(14).

PMID: 35886589 PMC: 9318163. DOI: 10.3390/ijerph19148737.

Retrospective Exposure Assessment Methods Used in Occupational Human Health Risk Assessment: A Systematic Review.

Borghi F, Mazzucchelli L, Campagnolo D, Rovelli S, Fanti G, Keller M Int J Environ Res Public Health. 2020; 17(17).

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Formaldehyde Exposure and Acute Myeloid Leukemia: A Review of the Literature.

Allegra A, Spatari G, Mattioli S, Curti S, Innao V, Ettari R Medicina (Kaunas). 2019; 55(10).

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References

Garabrant D, Olin R . Carcinogens and cancer risks in the microelectronics industry. Occup Med. 1986; 1(1):119-34. View

Hauptmann M, Stewart P, Lubin J, Beane Freeman L, Hornung R, Herrick R . Mortality from lymphohematopoietic malignancies and brain cancer among embalmers exposed to formaldehyde. J Natl Cancer Inst. 2009; 101(24):1696-708. PMC: 2794303. DOI: 10.1093/jnci/djp416. View

Andjelkovich D, Janszen D, Brown M, Richardson R, Miller F . Mortality of iron foundry workers: IV. Analysis of a subcohort exposed to formaldehyde. J Occup Environ Med. 1995; 37(7):826-37. DOI: 10.1097/00043764-199507000-00012. View

Rinsky R, Smith A, Hornung R, Filloon T, Young R, Okun A . Benzene and leukemia. An epidemiologic risk assessment. N Engl J Med. 1987; 316(17):1044-50. DOI: 10.1056/NEJM198704233161702. View

Meyers A, Pinkerton L, Hein M . Cohort mortality study of garment industry workers exposed to formaldehyde: update and internal comparisons. Am J Ind Med. 2013; 56(9):1027-39. DOI: 10.1002/ajim.22199. View

Beane Freeman L, Blair A, Lubin J, Stewart P, Hayes R, Hoover R . Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries: the National Cancer Institute Cohort. J Natl Cancer Inst. 2009; 101(10):751-61. PMC: 2684555. DOI: 10.1093/jnci/djp096. View

Marsh G, Youk A . Reevaluation of mortality risks from leukemia in the formaldehyde cohort study of the National Cancer Institute. Regul Toxicol Pharmacol. 2004; 40(2):113-24. DOI: 10.1016/j.yrtph.2004.05.012. View

Sorahan T, Waterhouse J, McKiernan M, Aston R . Cancer incidence and cancer mortality in a cohort of semiconductor workers. Br J Ind Med. 1985; 42(8):546-50. PMC: 1007525. DOI: 10.1136/oem.42.8.546. View

Darnton A, Miller B, MacCalman L, Galea K, Wilkinson S, Cherrie J . An updated investigation of cancer incidence and mortality at a Scottish semiconductor manufacturing facility with case-control and case-only studies of selected cancers. Occup Environ Med. 2012; 69(10):767-9. DOI: 10.1136/oemed-2011-100606. View

10.

McElvenny D, Darnton A, Hodgson J, Clarke S, Elliott R, Osman J . Investigation of cancer incidence and mortality at a Scottish semiconductor manufacturing facility. Occup Med (Lond). 2003; 53(7):419-30. DOI: 10.1093/occmed/kqg111. View

11.

Anttila A, Pukkala E, Sallmen M, HERNBERG S, Hemminki K . Cancer incidence among Finnish workers exposed to halogenated hydrocarbons. J Occup Environ Med. 1995; 37(7):797-806. DOI: 10.1097/00043764-199507000-00008. View

12.

. Chemical agents and related occupations. IARC Monogr Eval Carcinog Risks Hum. 2012; 100(Pt F):9-562. PMC: 4781612. View

13.

Beall C, Bender T, Cheng H, Herrick R, Kahn A, Matthews R . Mortality among semiconductor and storage device-manufacturing workers. J Occup Environ Med. 2005; 47(10):996-1014. DOI: 10.1097/01.jom.0000183094.42763.f0. View

14.

Axelson O, Selden A, Andersson K, Hogstedt C . Updated and expanded Swedish cohort study on trichloroethylene and cancer risk. J Occup Med. 1994; 36(5):556-62. View

15.

Kim E, Lee H, Ryu H, Park S, Kang S . Cases series of malignant lymphohematopoietic disorder in korean semiconductor industry. Saf Health Work. 2012; 2(2):122-34. PMC: 3431896. DOI: 10.5491/SHAW.2011.2.2.122. View

16.

Stern F, Beaumont J, Halperin W, Murthy L, Hills B, Fajen J . Mortality of chrome leather tannery workers and chemical exposures in tanneries. Scand J Work Environ Health. 1987; 13(2):108-17. DOI: 10.5271/sjweh.2073. View

17.

Lee H, Kim E, Park J, Kang S . Cancer mortality and incidence in korean semiconductor workers. Saf Health Work. 2012; 2(2):135-47. PMC: 3431897. DOI: 10.5491/SHAW.2011.2.2.135. View

18.

Boice Jr J, Marano D, Munro H, Chadda B, Signorello L, Tarone R . Cancer mortality among US workers employed in semiconductor wafer fabrication. J Occup Environ Med. 2010; 52(11):1082-97. DOI: 10.1097/JOM.0b013e3181f7e520. View

19.

Verbeek J . When Work is Related to Disease, What Establishes Evidence for a Causal Relation?. Saf Health Work. 2012; 3(2):110-6. PMC: 3440459. DOI: 10.5491/SHAW.2012.3.2.110. View

20.

Hansen J, Raaschou-Nielsen O, Christensen J, Johansen I, McLaughlin J, Lipworth L . Cancer incidence among Danish workers exposed to trichloroethylene. J Occup Environ Med. 2001; 43(2):133-9. DOI: 10.1097/00043764-200102000-00012. View