Combined Glucocorticoid and Antiviral Therapy of Hepatitis B Virus-related Liver Failure

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2015 Feb 27

PMID 25717260

Citations 7

Authors

Jan-Hendrik Bockmann

Maura Dandri

Stefan Luth

Nadine Pannicke

Ansgar W Lohse

Affiliations

Soon will be listed here.

Abstract

Acute hepatic failure due to hepatitis B virus (HBV) can occur both during primary infection as well as after reactivation of chronic infection. Guidelines recommend considering antiviral therapy in both situations, although evidence supporting this recommendation is weak. Since HBV is not directly cytopathic, the mechanism leading to fulminant hepatitis B is thought to be primarily immune-mediated. Therefore, immunosuppression combined with antiviral therapy might be a preferred therapeutic intervention in acute liver failure in hepatitis B. Here we report our favourable experience in three hepatitis B patients with fulminant hepatic failure who were treated by combining high-dose steroid therapy with standard antiviral treatment, which resulted in a rapid improvement of clinical and liver parameters.

Citing Articles

Serum Exosomal Long Noncoding RNA Growth Arrest-Specific 5 Predicts 3-Month Mortality in Acute-on-Chronic Hepatitis B Liver Failure.

Sun C, Han L, Wang K, Gao S J Inflamm Res. 2023; 16:4603-4616.

PMID: 37868833 PMC: 10590074. DOI: 10.2147/JIR.S423321.

Glucocorticoid Treatment Strategies in Liver Failure.

Ye C, Li W, Li L, Zhang K Front Immunol. 2022; 13:846091.

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Hypomethylation of thymosin β4 promoter is associated with glucocorticoid therapy in patients with acute-on-chronic hepatitis B-induced liver failure.

Wang H, Qian Y, Wang J, Fang Y, Fan Y, Liu H Int Health. 2022; 15(1):19-29.

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