Current Update on Synopsis of MiRNA Dysregulation in Neurological Disorders

Overview

Journal CNS Neurol Disord Drug Targets

Publisher Bentham Science Publishers

Specialties Neurology
Pharmacology

Date 2015 Feb 26

PMID 25714967

Citations 25

Authors

Mohammad A Kamal

Gohar Mushtaq

Nigel H Greig

Affiliations

Soon will be listed here.

Abstract

Aberrant expression of microRNAs (miRNAs) has been implicated in various neurological disorders (NDs) of the central nervous system such as Alzheimer disease, Parkinson's disease, Huntington disease, amyotrophic lateral sclerosis, schizophrenia and autism. If dysregulated miRNAs are identified in patients suffering from NDs, this may serve as a biomarker for the earlier diagnosis and monitoring of disease progression. Identifying the role of miRNAs in normal cellular processes and understanding how dysregulated miRNA expression is responsible for their neurological effects is also critical in the development of new therapeutic strategies for NDs. miRNAs hold great promise from a therapeutic point of view especially if it can be proved that a single miRNA has the ability to influence several target genes, making it possible for the researchers to potentially modify a whole disease phenotype by modulating a single miRNA molecule. Hence, better understanding of the mechanisms by which miRNA play a role in the pathogenesis of NDs may provide novel targets to scientists and researchers for innovative therapies.

Citing Articles

MicroRNA Expression in Asymptomatic Welders: Implications for Biomarker Discovery for Environmentally-Linked Neurodegenerative Disorders.

Bargues-Carot A, Prado-Rico J, Kawasawa Y, Cai J, Yanosky J, Zenitsky G medRxiv. 2025; .

PMID: 39990579 PMC: 11844587. DOI: 10.1101/2025.02.10.25322027.

MicroRNAs regulation in Parkinson's disease, and their potential role as diagnostic and therapeutic targets.

Shaheen N, Shaheen A, Osama M, Nashwan A, Bharmauria V, Flouty O NPJ Parkinsons Dis. 2024; 10(1):186.

PMID: 39369002 PMC: 11455891. DOI: 10.1038/s41531-024-00791-2.

miR-874-3p Alleviates Macrophage-Mediated Inflammatory Injury in Intracerebral Hemorrhage by Targeting HIPK2.

Shu Q, Lai R Cell Biochem Biophys. 2024; 83(1):953-961.

PMID: 39298065 DOI: 10.1007/s12013-024-01527-y.

MiRNA Dysregulation in Brain Injury: An Study to Clarify the Role of a MiRNA Set.

Sessa F, Pomara C, Schembari F, Esposito M, Capasso E, Pesaresi M Curr Neuropharmacol. 2024; 23(2):209-231.

PMID: 39129166 PMC: 11793054. DOI: 10.2174/1570159X22666240808124427.

Therapeutic prospects of microRNAs derived from mesenchymal stem cell extracellular vesicles in rheumatoid arthritis: a comprehensive overview.

Akbarzadeh A, Gerami M, Farrokhi M, Shapoori S, Jafarinia M Mol Cell Biochem. 2024; 480(3):1275-1286.

PMID: 39105963 DOI: 10.1007/s11010-024-05082-1.

References

Moreira P, Nunomura A, Nakamura M, Takeda A, Shenk J, Aliev G . Nucleic acid oxidation in Alzheimer disease. Free Radic Biol Med. 2008; 44(8):1493-505. DOI: 10.1016/j.freeradbiomed.2008.01.002. View

Zuccato C, Valenza M, Cattaneo E . Molecular mechanisms and potential therapeutical targets in Huntington's disease. Physiol Rev. 2010; 90(3):905-81. DOI: 10.1152/physrev.00041.2009. View

Cattaneo E, Zuccato C, Tartari M . Normal huntingtin function: an alternative approach to Huntington's disease. Nat Rev Neurosci. 2005; 6(12):919-30. DOI: 10.1038/nrn1806. View

Mates J, Perez-Gomez C, Nunez de Castro I . Antioxidant enzymes and human diseases. Clin Biochem. 2000; 32(8):595-603. DOI: 10.1016/s0009-9120(99)00075-2. View

Beveridge N, Tooney P, Carroll A, Gardiner E, Bowden N, Scott R . Dysregulation of miRNA 181b in the temporal cortex in schizophrenia. Hum Mol Genet. 2008; 17(8):1156-68. DOI: 10.1093/hmg/ddn005. View

Lukiw W, Zhao Y, Cui J . An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. J Biol Chem. 2008; 283(46):31315-22. PMC: 2581572. DOI: 10.1074/jbc.M805371200. View

Lim L, Lau N, Garrett-Engele P, Grimson A, Schelter J, Castle J . Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature. 2005; 433(7027):769-73. DOI: 10.1038/nature03315. View

Shtilbans A, Henchcliffe C . Biomarkers in Parkinson's disease: an update. Curr Opin Neurol. 2012; 25(4):460-5. DOI: 10.1097/WCO.0b013e3283550c0d. View

Winslow A, Rubinsztein D . The Parkinson disease protein α-synuclein inhibits autophagy. Autophagy. 2010; 7(4):429-31. PMC: 3127221. DOI: 10.4161/auto.7.4.14393. View

10.

Li F, Tsien J . Memory and the NMDA receptors. N Engl J Med. 2009; 361(3):302-3. PMC: 3703758. DOI: 10.1056/NEJMcibr0902052. View

11.

Al-Chalabi A, Jones A, Troakes C, King A, Al-Sarraj S, van den Berg L . The genetics and neuropathology of amyotrophic lateral sclerosis. Acta Neuropathol. 2012; 124(3):339-52. DOI: 10.1007/s00401-012-1022-4. View

12.

Sinha M, Ghose J, Bhattarcharyya N . Micro RNA -214,-150,-146a and-125b target Huntingtin gene. RNA Biol. 2011; 8(6):1005-21. DOI: 10.4161/rna.8.6.16035. View

13.

Williams A, Valdez G, Moresi V, Qi X, McAnally J, Elliott J . MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science. 2009; 326(5959):1549-54. PMC: 2796560. DOI: 10.1126/science.1181046. View

14.

Selkoe D . Alzheimer's disease is a synaptic failure. Science. 2002; 298(5594):789-91. DOI: 10.1126/science.1074069. View

15.

Wang W, Rajeev B, Stromberg A, Ren N, Tang G, Huang Q . The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J Neurosci. 2008; 28(5):1213-23. PMC: 2837363. DOI: 10.1523/JNEUROSCI.5065-07.2008. View

16.

De Felice B, Guida M, Guida M, Coppola C, De Mieri G, Cotrufo R . A miRNA signature in leukocytes from sporadic amyotrophic lateral sclerosis. Gene. 2012; 508(1):35-40. DOI: 10.1016/j.gene.2012.07.058. View

17.

Nunomura A, Moreira P, Castellani R, Lee H, Zhu X, Smith M . Oxidative damage to RNA in aging and neurodegenerative disorders. Neurotox Res. 2012; 22(3):231-48. DOI: 10.1007/s12640-012-9331-x. View

18.

Klein W . Synaptic targeting by A beta oligomers (ADDLS) as a basis for memory loss in early Alzheimer's disease. Alzheimers Dement. 2009; 2(1):43-55. DOI: 10.1016/j.jalz.2005.11.003. View

19.

Lukiw W . Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus. Neuroreport. 2007; 18(3):297-300. DOI: 10.1097/WNR.0b013e3280148e8b. View

20.

Seeburg D, Pak D, Sheng M . Polo-like kinases in the nervous system. Oncogene. 2005; 24(2):292-8. DOI: 10.1038/sj.onc.1208277. View