Histamine Receptors in Unstimulated Pancreatic Exocrine Secretion of the Rabbit

Overview

Journal Agents Actions

Specialty Pharmacology

Date 1989 Aug 1

PMID 2571245

Citations 2

Authors

J A Pariente

J A Madrid

G M Salido

Affiliations

Soon will be listed here.

Abstract

Histamine H2-receptor antagonists cimetidine and oxmetidine, H2-receptor agonist dimaprit, H1-receptor antagonist chlorpheniramine and H1-receptor agonist 2-thiazolylethylamine were tested for their effects on unstimulated pancreatic exocrine secretion in anaesthetized rabbits fitted with an acute pancreatic cannula. Intravenous administration of H1 agonist induces a dose-dependent increase in pancreatic secretion but H1 antagonist have the opposite effects. Intravenous administration of H2 antagonists induces effects similar the ones produced after H1 agonist infusion. The implications of H1 and H2 receptors on exocrine pancreatic secretion are discussed.

Citing Articles

Histaminergic modulation of hormonal control in the exocrine guinea-pig pancreas.

Alcon S, Pozo M, Salido G, Pariente J Inflamm Res. 1995; 44(5):207-11.

PMID: 7655995 DOI: 10.1007/BF01782260.

Cimetidine increases the pancreatic response to histamine.

Pariente J, Francis L, Salido G, Madrid J Agents Actions. 1990; 30(3-4):307-12.

PMID: 2386105 DOI: 10.1007/BF01966292.

References

TANKEL H, Lester L, Richman A, HOLLANDER F . A study of the pancreatic response to histamine in dogs with total gastrectomies. Gastroenterology. 1957; 32(4):642-50. View

REBOUD J, BEN ABDEL JLIL A, DESNUELLE P . [Variations in the enzyme content of the rat pancreas as a function of the composition of the diet]. Biochim Biophys Acta. 1962; 58:326-37. DOI: 10.1016/0006-3002(62)91016-8. View

CHARIOT J, Roze C, Scarpignato C . The effect of ranitidine on exocrine pancreatic secretion in the rat. Arch Int Pharmacodyn Ther. 1985; 274(1):166-76. View

Impicciatore M . Occurrence of H1- and H2-histamine receptors in the guinea-pig gall bladder in situ. Br J Pharmacol. 1978; 64(2):219-22. PMC: 1668321. DOI: 10.1111/j.1476-5381.1978.tb17292.x. View

Harvey C, Owen D . Cardiovascular studies with SK&F 93319, an antagonist of histamine at both H1- and H2-receptors. Br J Pharmacol. 1984; 83(2):427-32. PMC: 1987123. DOI: 10.1111/j.1476-5381.1984.tb16503.x. View

Lorenz W, Matejka E, SCHMAL A, Seidel W, Reimann H, Uhlig R . A phylogenetic study on the occurrence and distribution of histamine in the gastro-intestinal tract and other tissues of man and various animals. Comp Gen Pharmacol. 1973; 4(15):229-50. DOI: 10.1016/0010-4035(73)90004-9. View

Cavallini G, Vaona B, Bovo P, Mirachian R, Angelini G, SCURO L . Effect of histamine-H2-receptor antagonists on the exocrine pancreatic secretion. Acta Hepatogastroenterol (Stuttg). 1978; 25(5):388-90. View

Black J, Duncan W, Durant C, Ganellin C, Parsons E . Definition and antagonism of histamine H 2 -receptors. Nature. 1972; 236(5347):385-90. DOI: 10.1038/236385a0. View

Galmiche J, Colin R, Geffroy Y . Effect of cimetidine on pancreatic exocrine secretion. Lancet. 1977; 1(8012):647-8. DOI: 10.1016/s0140-6736(77)92079-7. View

10.

Liebow C, Franklin Jr J . Histamine stimulation of digestive enzyme secretion by in vitro rabbit pancreas. Dig Dis Sci. 1982; 27(3):234-41. DOI: 10.1007/BF01296922. View

11.

Madrid J, Salido G, Martinez de Victoria E, Mataix F . Cimetidine and postprandial pancreatic exocrine secretion in dogs. Agents Actions. 1985; 17(2):145-9. DOI: 10.1007/BF01966583. View

12.

Longstreth G, Go V, Malagelada J . Postprandial gastric, pancreatic, and biliary response to histamine H2-receptor antagonists active duodenal ulcer. Gastroenterology. 1977; 72(1):9-13. View

13.

Ash A, SCHILD H . Receptors mediating some actions of histamine. Br J Pharmacol Chemother. 1966; 27(2):427-39. PMC: 1510832. DOI: 10.1111/j.1476-5381.1966.tb01674.x. View

14.

Satoh Y, Satoh H, Honda F . Dopamine receptor blocking activity of sulpiride in the canine exocrine pancreas. Jpn J Pharmacol. 1980; 30(5):689-99. DOI: 10.1254/jjp.30.689. View

15.

Lorenz W, Schauer A, Heitland S, Calvoer R, Werle E . Biochemical and histochemical studies on the distribution of histamine in the digestive tract of man, dog and other mammals. Naunyn Schmiedebergs Arch Pharmakol. 1969; 265(1):81-100. DOI: 10.1007/BF01417211. View

16.

Lorenz W, Haubensak G, HUTZEL M, Werle E . [Histamine release in submaxillary gland and pancreas by parasympathomimetic drugs, peptide hormones, histamine and mepyramine]. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1968; 260(5):416-37. View

17.

MARCHIS-MOUREN G, Sarda L, DESNUELLE P . Purification of hog pancreatic lipase. Arch Biochem Biophys. 1959; 83(1):309-19. DOI: 10.1016/0003-9861(59)90036-0. View

18.

NOELTING G, BERNFELD P . On amylolytic enzymes; beta-amylase; activity assay and control of the absence of alpha-amylase. Helv Chim Acta. 1948; 31(1):286-90. DOI: 10.1002/hlca.19480310149. View

19.

Bradford M . A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976; 72:248-54. DOI: 10.1016/0003-2697(76)90527-3. View

20.

REBOUD J, MARCHIS-MOUREN G, Pasero L, Cozzone A, DESNUELLE P . [Adaptation of the rate of biosynthesis of pancreatic amylase and chymotrypsinogen A to starch-rich or protein-rich diets]. Biochim Biophys Acta. 1966; 117(2):351-67. View