Hyperkalemia and Potential Pitfalls of Sodium Polystyrene Sulfonate

Overview

Journal JAAPA

Publisher Wolters Kluwer

Specialty General Medicine

Date 2015 Feb 25

PMID 25710403

Citations 10

Authors

Timothy Nguyen

Daniella Ondrik

Oksana Zhufyak

Watson To

Sining He

Affiliations

Soon will be listed here.

Abstract

Sodium polystyrene sulfonate (SPS), FDA-approved more than 60 years ago for treating hyperkalemia, is an ion exchange resin that works by exchanging sodium for potassium in the colon. Though widely used in clinical practice, SPS use is not supported by well-designed clinical trials. In 2009, the FDA issued a warning that SPS was associated with colonic necrosis and other serious gastrointestinal adverse reactions. This article reviews the pros and cons of SPS therapy.

Citing Articles

Sodium zirconium cyclosilicate treatment and rates of emergency interventions for hyperkalaemia: a propensity-score weighted case-control study.

Marshall W, Curran G, Traynor J, Gillis K, Mark P, Lees J Clin Kidney J. 2024; 17(11):sfae313.

PMID: 39669394 PMC: 11635375. DOI: 10.1093/ckj/sfae313.

Hyperkalemia: Pharmacotherapies and Clinical Considerations.

Sinnathamby E, Banh K, Barham W, Hernandez T, De Witt A, Wenger D Cureus. 2024; 16(1):e52994.

PMID: 38406030 PMC: 10894645. DOI: 10.7759/cureus.52994.

Inpatient hospitalisation and mortality rate trends from 2004 to 2014 in the USA: a propensity score-matched case-control study of hyperkalaemia.

Tecson K, Baker R, Clariday L, McCullough P BMJ Open. 2022; 12(5):e059324.

PMID: 35589341 PMC: 9121480. DOI: 10.1136/bmjopen-2021-059324.

Phase I Study of the Pharmacodynamics and Safety of Sodium Zirconium Cyclosilicate in Healthy Chinese Adults.

Cheung T, Sun F, Zhao J, Qin Y, Nagard M Clin Pharmacol Drug Dev. 2022; 11(3):348-357.

PMID: 34997825 PMC: 9303228. DOI: 10.1002/cpdd.1055.

Growth characteristics of human bone marrow mesenchymal stromal cells at cultivation on synthetic polyelectrolyte nanofilms .

Mezhevikina L, Reshetnikov D, Fomkina M, Appazov N, Ibadullayeva S, Fesenko E Heliyon. 2021; 7(3):e06517.

PMID: 33817378 PMC: 8010635. DOI: 10.1016/j.heliyon.2021.e06517.