MicroRNAs and Cardiovascular Diseases

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2015 Feb 25

PMID 25710020

Citations 30

Authors

Tsuyoshi Nishiguchi

Toshio Imanishi

Takashi Akasaka

Affiliations

Soon will be listed here.

Abstract

Coronary artery diseases (CAD) and heart failure have high mortality rate in the world, although much progress has been made in this field in last two decades. There is still a clinical need for a novel diagnostic approach and a therapeutic strategy to decrease the incidence of CAD. MicroRNAs (miRNAs) are highly conserved noncoding small RNA molecules that regulate a large fraction of the genome by binding to complementary messenger RNA sequences, resulting in posttranscriptional gene silencing. Recent studies have shown that specific miRNAs are involved in whole stage of atherosclerosis, from endothelium dysfunction to plaque rupture. These findings suggest that miRNAs are potential biomarkers in early diagnosis and therapeutic targets in CAD. In the present review, we highlight the role of miRNAs in every stage of atherosclerosis, and discuss the prospects of miRNAs in the near future.

Citing Articles

Expression level of miR-146a is associated with the coronary lesion severity and clinical prognosis in patients with unstable angina pectoris.

Shi B, Wang X, Xue T, Liu J, Wu W, Luo Y Int J Cardiol Cardiovasc Risk Prev. 2025; 24:200367.

PMID: 39872631 PMC: 11770491. DOI: 10.1016/j.ijcrp.2025.200367.

MiRNAs as potential therapeutic targets and biomarkers for non-traumatic intracerebral hemorrhage.

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A meta-analysis of the relationship between circulating microRNA-155 and coronary artery disease.

Ran T, Chen J, Cheng Y, Zhang M, Mao M, Xiang R PLoS One. 2023; 18(4):e0274277.

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Circulating and Platelet MicroRNAs in Cardiovascular Risk Assessment and Antiplatelet Therapy Monitoring.

Procyk G, Klimczak-Tomaniak D, Sygitowicz G, Tomaniak M J Clin Med. 2022; 11(7).

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New Molecular and Organelle Alterations Linked to Down Syndrome Heart Disease.

Venegas-Zamora L, Bravo-Acuna F, Sigcho F, Gomez W, Bustamante-Salazar J, Pedrozo Z Front Genet. 2022; 12:792231.

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References

Xie C, Huang H, Sun X, Guo Y, Hamblin M, Ritchie R . MicroRNA-1 regulates smooth muscle cell differentiation by repressing Kruppel-like factor 4. Stem Cells Dev. 2010; 20(2):205-10. PMC: 3128754. DOI: 10.1089/scd.2010.0283. View

Kondkar A, Bray M, Leal S, Nagalla S, Liu D, Jin Y . VAMP8/endobrevin is overexpressed in hyperreactive human platelets: suggested role for platelet microRNA. J Thromb Haemost. 2009; 8(2):369-78. PMC: 3312605. DOI: 10.1111/j.1538-7836.2009.03700.x. View

Sabatel C, Malvaux L, Bovy N, Deroanne C, Lambert V, Gonzalez M . MicroRNA-21 exhibits antiangiogenic function by targeting RhoB expression in endothelial cells. PLoS One. 2011; 6(2):e16979. PMC: 3037403. DOI: 10.1371/journal.pone.0016979. View

Vickers K, Palmisano B, Shoucri B, Shamburek R, Remaley A . MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol. 2011; 13(4):423-33. PMC: 3074610. DOI: 10.1038/ncb2210. View

Shi R, Ge L, Zhou X, Ji W, Lu R, Zhang Y . Decreased platelet miR-223 expression is associated with high on-clopidogrel platelet reactivity. Thromb Res. 2013; 131(6):508-13. DOI: 10.1016/j.thromres.2013.02.015. View

Rautou P, Vion A, Amabile N, Chironi G, Simon A, Tedgui A . Microparticles, vascular function, and atherothrombosis. Circ Res. 2011; 109(5):593-606. DOI: 10.1161/CIRCRESAHA.110.233163. View

Kearney M, Duncan E, Kahn M, Wheatcroft S . Insulin resistance and endothelial cell dysfunction: studies in mammalian models. Exp Physiol. 2007; 93(1):158-63. DOI: 10.1113/expphysiol.2007.039172. View

Poy M, Hausser J, Trajkovski M, Braun M, Collins S, Rorsman P . miR-375 maintains normal pancreatic alpha- and beta-cell mass. Proc Natl Acad Sci U S A. 2009; 106(14):5813-8. PMC: 2656556. DOI: 10.1073/pnas.0810550106. View

Tummala P, Chen X, Sundell C, Laursen J, Hammes C, Alexander R . Angiotensin II induces vascular cell adhesion molecule-1 expression in rat vasculature: A potential link between the renin-angiotensin system and atherosclerosis. Circulation. 1999; 100(11):1223-9. DOI: 10.1161/01.cir.100.11.1223. View

10.

Dimri G, Lee X, Basile G, Acosta M, Scott G, Roskelley C . A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A. 1995; 92(20):9363-7. PMC: 40985. DOI: 10.1073/pnas.92.20.9363. View

11.

Diehl P, Fricke A, Sander L, Stamm J, Bassler N, Htun N . Microparticles: major transport vehicles for distinct microRNAs in circulation. Cardiovasc Res. 2012; 93(4):633-44. PMC: 3291092. DOI: 10.1093/cvr/cvs007. View

12.

Jansen F, Yang X, Hoelscher M, Cattelan A, Schmitz T, Proebsting S . Endothelial microparticle-mediated transfer of MicroRNA-126 promotes vascular endothelial cell repair via SPRED1 and is abrogated in glucose-damaged endothelial microparticles. Circulation. 2013; 128(18):2026-38. DOI: 10.1161/CIRCULATIONAHA.113.001720. View

13.

Wu X, Fan W, Fang R, Wu G . Regulation of microRNA-155 in endothelial inflammation by targeting nuclear factor (NF)-κB P65. J Cell Biochem. 2014; 115(11):1928-36. DOI: 10.1002/jcb.24864. View

14.

Donners M, Wolfs I, Stoger L, van der Vorst E, Pottgens C, Heymans S . Hematopoietic miR155 deficiency enhances atherosclerosis and decreases plaque stability in hyperlipidemic mice. PLoS One. 2012; 7(4):e35877. PMC: 3338496. DOI: 10.1371/journal.pone.0035877. View

15.

Minamino T, Miyauchi H, Yoshida T, Ishida Y, Yoshida H, Komuro I . Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation. 2002; 105(13):1541-4. DOI: 10.1161/01.cir.0000013836.85741.17. View

16.

Kloosterman W, Lagendijk A, Ketting R, Moulton J, Plasterk R . Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet development. PLoS Biol. 2007; 5(8):e203. PMC: 1925136. DOI: 10.1371/journal.pbio.0050203. View

17.

Huang R, Hu G, Lin B, Lin Z, Sun C . MicroRNA-155 silencing enhances inflammatory response and lipid uptake in oxidized low-density lipoprotein-stimulated human THP-1 macrophages. J Investig Med. 2010; 58(8):961-7. DOI: 10.231/JIM.0b013e3181ff46d7. View

18.

Ikejima H, Imanishi T, Tsujioka H, Kashiwagi M, Kuroi A, Tanimoto T . Upregulation of fractalkine and its receptor, CX3CR1, is associated with coronary plaque rupture in patients with unstable angina pectoris. Circ J. 2009; 74(2):337-45. DOI: 10.1253/circj.cj-09-0484. View

19.

Yang G, Pei Y, Cao Q, Wang R . MicroRNA-21 represses human cystathionine gamma-lyase expression by targeting at specificity protein-1 in smooth muscle cells. J Cell Physiol. 2011; 227(9):3192-200. DOI: 10.1002/jcp.24006. View

20.

Kang H, Davis-Dusenbery B, Nguyen P, Lal A, Lieberman J, Van Aelst L . Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. J Biol Chem. 2011; 287(6):3976-86. PMC: 3281737. DOI: 10.1074/jbc.M111.303156. View