Production of Dioxygen in the Dark: Dismutases of Oxyanions

Overview

Journal Met Ions Life Sci

Publisher De Gruyter

Specialties Biochemistry
Chemistry

Date 2015 Feb 25

PMID 25707466

Citations 6

Authors

Jennifer L DuBois

Sunil Ojha

Affiliations

Soon will be listed here.

Abstract

O₂-generating reactions are exceedingly rare in biology and difficult to mimic synthetically. Perchlorate-respiring bacteria enzymatically detoxify chlorite (ClO₂(-) ), the end product of the perchlorate (ClO(4)(-) ) respiratory pathway, by rapidly converting it to dioxygen (O₂) and chloride (Cl(-)). This reaction is catalyzed by a heme-containing protein, called chlorite dismutase (Cld), which bears no structural or sequence relationships with known peroxidases or other heme proteins and is part of a large family of proteins with more than one biochemical function. The original assumptions from the 1990s that perchlorate is not a natural product and that perchlorate respiration might be confined to a taxonomically narrow group of species have been called into question, as have the roles of perchlorate respiration and Cld-mediated reactions in the global biogeochemical cycle of chlorine. In this chapter, the chemistry and biochemistry of Cld-mediated O₂generation, as well as the biological and geochemical context of this extraordinary reaction, are described.

Citing Articles

Unique Biradical Intermediate in the Mechanism of the Heme Enzyme Chlorite Dismutase.

Puschmann J, Mahor D, de Geus D, Strampraad M, Srour B, Hagen W ACS Catal. 2021; 11(23):14533-14544.

PMID: 34888122 PMC: 8650003. DOI: 10.1021/acscatal.1c03432.

Effect of Chlorination on Microbiological Quality of Effluent of a Full-Scale Wastewater Treatment Plant.

Zerva I, Remmas N, Kagalou I, Melidis P, Ariantsi M, Sylaios G Life (Basel). 2021; 11(1).

PMID: 33477775 PMC: 7832327. DOI: 10.3390/life11010068.

Structure and reactivity of chlorite dismutase nitrosyls.

Geeraerts Z, Heskin A, DuBois J, Rodgers K, Lukat-Rodgers G J Inorg Biochem. 2020; 211:111203.

PMID: 32768737 PMC: 7749827. DOI: 10.1016/j.jinorgbio.2020.111203.

Microbial Synthesis and Transformation of Inorganic and Organic Chlorine Compounds.

Atashgahi S, Liebensteiner M, Janssen D, Smidt H, Stams A, Sipkema D Front Microbiol. 2019; 9:3079.

PMID: 30619161 PMC: 6299022. DOI: 10.3389/fmicb.2018.03079.

Distinguishing Active Site Characteristics of Chlorite Dismutases with Their Cyanide Complexes.

Geeraerts Z, Celis A, Mayfield J, Lorenz M, Rodgers K, DuBois J Biochemistry. 2018; 57(9):1501-1516.

PMID: 29406727 PMC: 5849076. DOI: 10.1021/acs.biochem.7b01278.

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