Primary Cilia in Tumor Biology: The Primary Cilium As a Therapeutic Target in Cholangiocarcinoma

Overview

Journal Curr Drug Targets

Publisher Bentham Science Publishers

Specialty Pharmacology

Date 2015 Feb 24

PMID 25706257

Citations 21

Authors

Sergio A Gradilone

Maria J Lorenzo Pisarello

Nicholas F LaRusso

Affiliations

Soon will be listed here.

Abstract

Cilia are microtubule-based organelles, which are ubiquitously expressed in epithelial cells. Cholangiocytes, the epithelial cells lining the biliary tree, have primary cilia extending from their apical plasma membrane into the ductal lumen, where the cilia function as multisensory organelles transducing environmental cues into the cell interior. The decrease or loss of primary cilia has been described in several malignancies, including cholangiocarcinoma, suggesting that the loss of cilia is a common occurrence in neoplastic transformation. In this short review, we describe the expression of cilia in several cancers, explore the mechanisms and consequences of ciliary loss, and discuss the potential use of the primary cilia as therapeutic targets.

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