Plasmid-Mediated Antibiotic Resistance and Virulence in Gram-negatives: the Paradigm

Overview

Journal Microbiol Spectr

Specialty Microbiology

Date 2015 Feb 24

PMID 25705573

Citations 35

Authors

Maria S Ramirez

German M Traglia

David L Lin

Tung Tran

Marcelo E Tolmasky

Affiliations

Soon will be listed here.

Abstract

Plasmids harbor genes coding for specific functions including virulence factors and antibiotic resistance that permit bacteria to survive the hostile environment found in the host and resist treatment. Together with other genetic elements such as integrons and transposons, and using a variety of mechanisms, plasmids participate in the dissemination of these traits resulting in the virtual elimination of barriers among different kinds of bacteria. In this article we review the current information about physiology and role in virulence and antibiotic resistance of plasmids from the gram-negative opportunistic pathogen . This bacterium has acquired multidrug resistance and is the causative agent of serious communityand hospital-acquired infections. It is also included in the recently defined ESKAPE group of bacteria that cause most of US hospital infections.

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References

Rashid T, Ebringer A . Ankylosing spondylitis is linked to Klebsiella--the evidence. Clin Rheumatol. 2006; 26(6):858-64. DOI: 10.1007/s10067-006-0488-7. View

Yu V, Hansen D, Ko W, Sagnimeni A, Klugman K, von Gottberg A . Virulence characteristics of Klebsiella and clinical manifestations of K. pneumoniae bloodstream infections. Emerg Infect Dis. 2008; 13(7):986-93. PMC: 2878244. DOI: 10.3201/eid1307.070187. View

Stephens C, Murray W . Pathogen evolution: How good bacteria go bad. Curr Biol. 2001; 11(2):R53-6. DOI: 10.1016/s0960-9822(01)00012-4. View

Tran T, Andres P, Petroni A, Soler-Bistue A, Albornoz E, Zorreguieta A . Small plasmids harboring qnrB19: a model for plasmid evolution mediated by site-specific recombination at oriT and Xer sites. Antimicrob Agents Chemother. 2012; 56(4):1821-7. PMC: 3318318. DOI: 10.1128/AAC.06036-11. View

Ramirez M, Nikolaidis N, Tolmasky M . Rise and dissemination of aminoglycoside resistance: the aac(6')-Ib paradigm. Front Microbiol. 2013; 4:121. PMC: 3656343. DOI: 10.3389/fmicb.2013.00121. View

Guiney D, Fang F, Krause M, Libby S . Plasmid-mediated virulence genes in non-typhoid Salmonella serovars. FEMS Microbiol Lett. 1994; 124(1):1-9. DOI: 10.1111/j.1574-6968.1994.tb07253.x. View

Le Minh P, Devroede N, Massant J, Maes D, Charlier D . Insights into the architecture and stoichiometry of Escherichia coli PepA*DNA complexes involved in transcriptional control and site-specific DNA recombination by atomic force microscopy. Nucleic Acids Res. 2009; 37(5):1463-76. PMC: 2655662. DOI: 10.1093/nar/gkn1078. View

Poulou A, Voulgari E, Vrioni G, Koumaki V, Xidopoulos G, Chatzipantazi V . Outbreak caused by an ertapenem-resistant, CTX-M-15-producing Klebsiella pneumoniae sequence type 101 clone carrying an OmpK36 porin variant. J Clin Microbiol. 2013; 51(10):3176-82. PMC: 3811621. DOI: 10.1128/JCM.01244-13. View

Villa L, Poirel L, Nordmann P, Carta C, Carattoli A . Complete sequencing of an IncH plasmid carrying the blaNDM-1, blaCTX-M-15 and qnrB1 genes. J Antimicrob Chemother. 2012; 67(7):1645-50. DOI: 10.1093/jac/dks114. View

10.

Suzuki K, Nakamura A, Enokiya T, Iwashita Y, Tomatsu E, Muraki Y . Septic arthritis subsequent to urosepsis caused by hypermucoviscous Klebsiella pneumoniae. Intern Med. 2013; 52(14):1641-5. DOI: 10.2169/internalmedicine.52.0175. View

11.

Song Y, Tong Z, Wang J, Wang L, Guo Z, Han Y . Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans. DNA Res. 2004; 11(3):179-97. DOI: 10.1093/dnares/11.3.179. View

12.

Bojer M, Struve C, Ingmer H, Hansen D, Krogfelt K . Heat resistance mediated by a new plasmid encoded Clp ATPase, ClpK, as a possible novel mechanism for nosocomial persistence of Klebsiella pneumoniae. PLoS One. 2010; 5(11):e15467. PMC: 2976762. DOI: 10.1371/journal.pone.0015467. View

13.

Montealegre M, Maya J, Correa A, Espinal P, Mojica M, Ruiz S . First identification of OXA-72 carbapenemase from Acinetobacter pittii in Colombia. Antimicrob Agents Chemother. 2012; 56(7):3996-8. PMC: 3393383. DOI: 10.1128/AAC.05628-11. View

14.

Nassif X, Fournier J, Arondel J, Sansonetti P . Mucoid phenotype of Klebsiella pneumoniae is a plasmid-encoded virulence factor. Infect Immun. 1989; 57(2):546-52. PMC: 313131. DOI: 10.1128/iai.57.2.546-552.1989. View

15.

Sarno R, McGillivary G, Sherratt D, Actis L, Tolmasky M . Complete nucleotide sequence of Klebsiella pneumoniae multiresistance plasmid pJHCMW1. Antimicrob Agents Chemother. 2002; 46(11):3422-7. PMC: 128720. DOI: 10.1128/AAC.46.11.3422-3427.2002. View

16.

Tran T, Sherratt D, Tolmasky M . fpr, a deficient Xer recombination site from a Salmonella plasmid, fails to confer stability by dimer resolution: comparative studies with the pJHCMW1 mwr site. J Bacteriol. 2009; 192(3):883-7. PMC: 2812456. DOI: 10.1128/JB.01082-09. View

17.

Reijns M, Lu Y, Leach S, Colloms S . Mutagenesis of PepA suggests a new model for the Xer/cer synaptic complex. Mol Microbiol. 2005; 57(4):927-41. DOI: 10.1111/j.1365-2958.2005.04716.x. View

18.

Carattoli A . Plasmids and the spread of resistance. Int J Med Microbiol. 2013; 303(6-7):298-304. DOI: 10.1016/j.ijmm.2013.02.001. View

19.

Pasquali F, Kehrenberg C, Manfreda G, Schwarz S . Physical linkage of Tn3 and part of Tn1721 in a tetracycline and ampicillin resistance plasmid from Salmonella Typhimurium. J Antimicrob Chemother. 2005; 55(4):562-5. DOI: 10.1093/jac/dkh553. View

20.

Tolmasky M, Roberts M, Woloj M, Crosa J . Molecular cloning of amikacin resistance determinants from a Klebsiella pneumoniae plasmid. Antimicrob Agents Chemother. 1986; 30(2):315-20. PMC: 180541. DOI: 10.1128/AAC.30.2.315. View