Enteric Hyperoxaluria: an Important Cause of End-stage Kidney Disease

Overview

Journal Nephrol Dial Transplant

Publisher Oxford University Press

Specialties General Surgery
Nephrology

Date 2015 Feb 22

PMID 25701816

Citations 47

Authors

Lama Nazzal

Sonika Puri

David S Goldfarb

Affiliations

Soon will be listed here.

Abstract

Hyperoxaluria is a frequent complication of inflammatory bowel diseases, ileal resection and Roux-en-Y gastric bypass and is well-known to cause nephrolithiasis and nephrocalcinosis. The associated prevalence of chronic kidney disease and end-stage kidney disease (ESKD) is less clear but may be more consequential than recognized. In this review, we highlight three cases of ESKD due to enteric hyperoxaluria following small bowel resections. We review current information on the pathophysiology, complications and treatment of this complex disease.

Citing Articles

Inflammatory Bowel Diseases and Nephropathies: Exploring the Gut-Kidney Axis.

De Sire R, La Mantia A, Bonacci L, Testa A, Guarino A, Rispo A Life (Basel). 2025; 14(12.

PMID: 39768250 PMC: 11678131. DOI: 10.3390/life14121541.

Complex system modelling reveals oxalate homeostasis is driven by diverse oxalate-degrading bacteria.

Mukherjee S, Batagello C, Adler A, Agudelo J, Zampini A, Suryavanshi M bioRxiv. 2024; .

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Opportunities in Primary and Enteric Hyperoxaluria at the Cross-Roads Between the Clinic and Laboratory.

Cellini B, Baum M, Frishberg Y, Groothoff J, Harris P, Hulton S Kidney Int Rep. 2024; 9(11):3083-3096.

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Insights into renal and urological complications of inflammatory bowel disease.

Singh A, Khanna T, Mahendru D, Kahlon J, Kumar V, Sohal A World J Nephrol. 2024; 13(3):96574.

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From Smoothies to Dialysis: The Impact of Oxalate Nephropathy.

Samra M, Gupta I Cureus. 2024; 16(8):e67409.

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