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Angiotensin II Receptor Antagonists (AT-blockers, ARBs, Sartans): Similarities and Differences

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Journal Neth Heart J
Date 2015 Feb 20
PMID 25696573
Citations 4
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Abstract

A survey is presented of the registered non-peptidergic angiotensin II receptor antagonists (AT blockers, ARBs, sartans) and their general properties and similarities. Accordingly, their receptor profile, pharmacokinetic and therapeutic applications are discussed. In addition, attention is paid to the individual characteristics of the AT blockers now available. A few components of this category offer additional potentially beneficial properties, owing to their pharmacological or metabolic characteristics. Such additional properties are critically discussed for eprosartan, losartan, telmisartan and valsartan.

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References
1.
Viberti G, Wheeldon N . Microalbuminuria reduction with valsartan in patients with type 2 diabetes mellitus: a blood pressure-independent effect. Circulation. 2002; 106(6):672-8. DOI: 10.1161/01.cir.0000024416.33113.0a. View

2.
Parving H, Lehnert H, Brochner-Mortensen J, Gomis R, Andersen S, Arner P . The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med. 2001; 345(12):870-8. DOI: 10.1056/NEJMoa011489. View

3.
Pfeffer M, McMurray J, Velazquez E, Rouleau J, Kober L, Maggioni A . Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N Engl J Med. 2003; 349(20):1893-906. DOI: 10.1056/NEJMoa032292. View

4.
Barnett A, Bain S, Bouter P, Karlberg B, Madsbad S, Jervell J . Angiotensin-receptor blockade versus converting-enzyme inhibition in type 2 diabetes and nephropathy. N Engl J Med. 2004; 351(19):1952-61. DOI: 10.1056/NEJMoa042274. View

5.
Dzielak D . Comparative pharmacology of the angiotensin II receptor antagonists. Expert Opin Investig Drugs. 2005; 7(5):741-51. DOI: 10.1517/13543784.7.5.741. View