Control of a Hair Bundle's Mechanosensory Function by Its Mechanical Load

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2015 Feb 19

PMID 25691749

Citations 26

Authors

Joshua D Salvi

Daibhid O Maoileidigh

Brian A Fabella

Melanie Tobin

A J Hudspeth

Affiliations

Soon will be listed here.

Abstract

Hair cells, the sensory receptors of the internal ear, subserve different functions in various receptor organs: they detect oscillatory stimuli in the auditory system, but transduce constant and step stimuli in the vestibular and lateral-line systems. We show that a hair cell's function can be controlled experimentally by adjusting its mechanical load. By making bundles from a single organ operate as any of four distinct types of signal detector, we demonstrate that altering only a few key parameters can fundamentally change a sensory cell's role. The motions of a single hair bundle can resemble those of a bundle from the amphibian vestibular system, the reptilian auditory system, or the mammalian auditory system, demonstrating an essential similarity of bundles across species and receptor organs.

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