» Articles » PMID: 25689318

Unraveling the Swine Genome: Implications for Human Health

Overview
Publisher Annual Reviews
Date 2015 Feb 18
PMID 25689318
Citations 42
Authors
Affiliations
Soon will be listed here.
Abstract

The pig was first used in biomedical research in ancient Greece and over the past few decades has quickly grown into an important biomedical research tool. Pigs have genetic and physiological traits similar to humans, which make them one of the most useful and versatile animal models. Owing to these similarities, data generated from porcine models are more likely to lead to viable human treatments than those from murine work. In addition, the similarity in size and physiology to humans allows pigs to be used for many experimental approaches not feasible in mice. Research areas that employ pigs range from neonatal development to translational models for cancer therapy. Increasing numbers of porcine models are being developed since the release of the swine genome sequence, and the development of additional porcine genomic and epigenetic resources will further their use in biomedical research.

Citing Articles

Merging metabolomics and genomics provides a catalog of genetic factors that influence molecular phenotypes in pigs linking relevant metabolic pathways.

Bovo S, Ribani A, Fanelli F, Galimberti G, Martelli P, Trevisi P Genet Sel Evol. 2025; 57(1):11.

PMID: 40050712 PMC: 11887101. DOI: 10.1186/s12711-025-00960-8.


Göttingen minipigs present with significant regeneration kinetics after sphincter injury compared to German landrace gilts; a feasibility study.

Knoll J, Harland N, Amend B, Stenzl A, Aicher W BMC Vet Res. 2025; 21(1):75.

PMID: 39966915 PMC: 11834614. DOI: 10.1186/s12917-025-04529-x.


Genetic engineering drives the breakthrough of pig models in liver disease research.

Xu C, Fang X, Xu X, Wei X Liver Res. 2025; 8(3):131-140.

PMID: 39957748 PMC: 11771255. DOI: 10.1016/j.livres.2024.09.003.


A pilot pharmacokinetic and Metabolite identification study of Erinacine A in a Single landrace pig model.

Chen Y, Lin T, Li I, Tsung L, Hou C, Yang C Heliyon. 2024; 10(18):e37850.

PMID: 39315194 PMC: 11417322. DOI: 10.1016/j.heliyon.2024.e37850.


The Mechanism of Action of the Active Ingredients of against Porcine Epidemic Diarrhea Was Investigated Using Network Pharmacology and Molecular Docking Technology.

Zou H, Niu Z, Tang Z, Cheng P, Yin Y, Luo G Viruses. 2024; 16(8).

PMID: 39205203 PMC: 11360715. DOI: 10.3390/v16081229.