Fetal Cocaine Exposure: Neurologic Effects and Sensory-Motor Delays

Overview

Journal Phys Occup Ther Pediatr

Specialty Pediatrics

Date 2015 Feb 18

PMID 25688173

Citations 5

Authors

Robert E Arendt

Sonnia Minnes

Lynn T Singer

Affiliations

Soon will be listed here.

Abstract

Research on animal models demonstrates that fetal cocaine exposure results in neurologic deficits in memory and learning. Although drug effects on human infants are difficult to separate from other environmental influences of a drug-using lifestyle, studies suggest that infants exposed to cocaine in utero have reduced growth, delays in sensory-motor development, attentional deficits, and depressed responsivity to social stimulation. Standard interventions to promote behavioral state regulation in affected infants may be helpful when parents are capable of participating.

Citing Articles

Chronic Cocaine Use and Parkinson's Disease: An Interpretative Model.

Carbone M, Maremmani I Int J Environ Res Public Health. 2024; 21(8).

PMID: 39200714 PMC: 11354226. DOI: 10.3390/ijerph21081105.

Effect of Cocaine on Potassium-Evoked Release of Glutamate From Fetal Rat Brain Synaptosomes.

Penning D, Jones B, Fayed M, Han X, Brodie C Cureus. 2022; 14(10):e30075.

PMID: 36381732 PMC: 9637459. DOI: 10.7759/cureus.30075.

Mass Spectrometry-Based Proteome Profiling of Extracellular Vesicles Derived from the Cerebrospinal Fluid of Adult Rhesus Monkeys Exposed to Cocaine throughout Gestation.

Rather H, Mishra S, Su Y, Kumar A, Singh S, Misra B Biomolecules. 2022; 12(4).

PMID: 35454099 PMC: 9026784. DOI: 10.3390/biom12040510.

Motor development of cocaine-exposed children at age two years.

Arendt R, Angelopoulos J, Salvator A, Singer L Pediatrics. 1999; 103(1):86-92.

PMID: 9917444 PMC: 4220289. DOI: 10.1542/peds.103.1.86.

Relationship of prenatal cocaine exposure and maternal postpartum psychological distress to child developmental outcome.

Singer L, Arendt R, Farkas K, Minnes S, Huang J, Yamashita T Dev Psychopathol. 1997; 9(3):473-89.

PMID: 9327234 PMC: 4213812. DOI: 10.1017/s0954579497001259.

References

Singer L, Arendt R, Minnes S . Neurodevelopmental effects of cocaine. Clin Perinatol. 1993; 20(1):245-62. PMC: 4181371. View

Legido A, Clancy R, Spitzer A, Finnegan L . Electroencephalographic and behavioral-state studies in infants of cocaine-addicted mothers. Am J Dis Child. 1992; 146(6):748-52. DOI: 10.1001/archpedi.1992.02160180108027. View

Singer L, Arendt R, Minnes S, Farkas K, Yamashita T, Kliegman R . Increased psychological distress in post-partum, cocaine-using mothers. J Subst Abuse. 1995; 7(2):165-74. PMC: 4189084. DOI: 10.1016/0899-3289(95)90002-0. View

Wheeden A, Scafidi F, Field T, Ironson G, Valdeon C, Bandstra E . Massage effects on cocaine-exposed preterm neonates. J Dev Behav Pediatr. 1993; 14(5):318-22. View

Kramer L, Locke G, Ogunyemi A, Nelson L . Neonatal cocaine-related seizures. J Child Neurol. 1990; 5(1):60-4. DOI: 10.1177/088307389000500115. View

Dominguez R, Slopis J, Bohan T . Brain and ocular abnormalities in infants with in utero exposure to cocaine and other street drugs. Am J Dis Child. 1991; 145(6):688-95. DOI: 10.1001/archpedi.1991.02160060106030. View

Heyser C, Chen W, Miller J, Spear N, Spear L . Prenatal cocaine exposure induces deficits in Pavlovian conditioning and sensory preconditioning among infant rat pups. Behav Neurosci. 1990; 104(6):955-63. DOI: 10.1037//0735-7044.104.6.955. View

Singer L, Yamashita T, Hawkins S, Cairns D, Baley J, Kliegman R . Increased incidence of intraventricular hemorrhage and developmental delay in cocaine-exposed, very low birth weight infants. J Pediatr. 1994; 124(5 Pt 1):765-71. PMC: 4181569. DOI: 10.1016/s0022-3476(05)81372-1. View

Riley E, FOSS J . The acquisition of passive avoidance, active avoidance, and spatial navigation tasks by animals prenatally exposed to cocaine. Neurotoxicol Teratol. 1991; 13(5):559-64. DOI: 10.1016/0892-0362(91)90066-6. View

10.

Dusick A, Covert R, Schreiber M, Yee G, Browne S, Moore C . Risk of intracranial hemorrhage and other adverse outcomes after cocaine exposure in a cohort of 323 very low birth weight infants. J Pediatr. 1993; 122(3):438-45. DOI: 10.1016/s0022-3476(05)83438-9. View

11.

Tennyson V, Gershon P, Budininkas-Schoenebeck M, Rothman T . Effects of extended periods of reserpine and α-methyl-p-tyrosine treatment on the development of the putamen in fetal rabbits. Int J Dev Neurosci. 2014; 1(4-5):305-18. DOI: 10.1016/0736-5748(83)90033-3. View

12.

Shih L, Cone-Wesson B, Reddix B . Effects of maternal cocaine abuse on the neonatal auditory system. Int J Pediatr Otorhinolaryngol. 1988; 15(3):245-51. DOI: 10.1016/0165-5876(88)90079-1. View

13.

Singer L, Arendt R, Song L, Warshawsky E, Kliegman R . Direct and indirect interactions of cocaine with childbirth outcomes. Arch Pediatr Adolesc Med. 1994; 148(9):959-64. PMC: 10246323. DOI: 10.1001/archpedi.1994.02170090073014. View

14.

Chasnoff I, Bussey M, Savich R, Stack C . Perinatal cerebral infarction and maternal cocaine use. J Pediatr. 1986; 108(3):456-9. DOI: 10.1016/s0022-3476(86)80896-4. View

15.

HUFFMAN D, Price B, Langel L . Therapeutic handling techniques for the infant affected by cocaine. Neonatal Netw. 1994; 13(5):9-13. View

16.

Schneider J, Lee W, Chasnoff I . Field testing of the movement assessment of infants. Phys Ther. 1988; 68(3):321-7. DOI: 10.1093/ptj/68.3.321. View

17.

Cregler L, Mark H . Medical complications of cocaine abuse. N Engl J Med. 1986; 315(23):1495-500. DOI: 10.1056/NEJM198612043152327. View

18.

Chasnoff I, Burns K, Burns W . Cocaine use in pregnancy: perinatal morbidity and mortality. Neurotoxicol Teratol. 1987; 9(4):291-3. DOI: 10.1016/0892-0362(87)90017-1. View

19.

Chasnoff I, Burns W, Schnoll S, Burns K . Cocaine use in pregnancy. N Engl J Med. 1985; 313(11):666-9. DOI: 10.1056/NEJM198509123131105. View

20.

Schwartz K, Cohen J . Subarachnoid hemorrhage precipitated by cocaine snorting. Arch Neurol. 1984; 41(7):705. DOI: 10.1001/archneur.1984.04050180027008. View