Exploring the Tumors of Multiple Endocrine Neoplasia Type 1 in Mouse Models for Basic and Preclinical Studies

Overview

Journal Int J Endocr Oncol

Date 2015 Feb 17

PMID 25685317

Citations 13

Authors

Sunita K Agarwal

Affiliations

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Abstract

Most patients (70-90%) with the multiple endocrine neoplasia type 1 (MEN1) syndrome possess germline heterozygous mutations in that predisposes to tumors of multiple endocrine and nonendocrine tissues. Some endocrine tumors of the kinds seen in MEN1 that occur sporadically in the general population also possess somatic mutations in . Interestingly, the endocrine tumors of MEN1 are recapitulated in mouse models of loss that serve as a valuable resource to understand the pathophysiology and molecular basis of tumorigenesis. Exploring these endocrine tumors in mouse models using , and methods can help to follow the process of tumorigenesis, and can be useful for preclinical testing of therapeutics and understanding their mechanisms of action.

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