Bacterial Histone-like Proteins: Roles in Stress Resistance

Overview

Journal Curr Genet

Specialty Genetics

Date 2015 Feb 14

PMID 25677732

Citations 7

Authors

Ge Wang

Robert J Maier

Affiliations

Soon will be listed here.

Abstract

Histone-like proteins (HLPs) are small and basic bacterial proteins that are associated with a nucleoid and play roles in maintaining DNA architecture and regulating DNA transactions such as replication, recombination/repair and transcription. The studies on HLPs from a variety of bacterial species in recent years are summarized in this mini-review. A recent study reported a novel DNA-binding protein (HP119) in Helicobacter pylori that shows some HLP features. It plays a large role in aiding bacterial stress resistance. We provide herein additional evidence that HP119 is a nucleoid-associated protein, and present some perspectives for future study.

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