Association Between Plasma Leptin Level and Systemic Inflammatory Markers in Patients with Aggressive Periodontitis

Overview

Journal Chin Med J (Engl)

Specialty General Medicine

Date 2015 Feb 13

PMID 25673458

Citations 5

Authors

Dong Shi

Yun-Yu Liu

Wei Li

Xin Zhang

Xiao-Jun Sun

Li Xu

Li Zhang

Zhi-Bin Chen

Huan-Xin Meng

Affiliations

Soon will be listed here.

Abstract

Background: Increasing evidence supports an association between periodontitis and systemic diseases. Leptin is involved both in the energy metabolism and inflammatory processes and is suggested to be a link between periodontal infection and systemic health. The present study aimed to evaluate the peripheral leptin concentration in patients with aggressive periodontitis (AgP) and to explore the relationship between leptin and systemic inflammation.

Methods: Ninety patients with AgP visiting the Clinic of the Periodontology Department, Peking University School and Hospital of Stomatology between July 2001 and May 2006, and 44 healthy controls (staff and student volunteers in the same institute) were recruited. Plasma levels of leptin and inflammatory cytokines including interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) were measured by enzyme-linked immunosorbent assay. Correlation and multiple linear regression analysis were performed to analyze the association between plasma leptin level and other variables.

Results: Plasma leptin level of AgP group was significantly higher than that of the control group (19.7 ± 4.4 ng/ml vs. 7.5 ± 1.3 ng/ml, P < 0.01). After controlling for age, gender, and body mass index, positive correlation was observed between plasma leptin concentration and log-transformed levels of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α and CRP), and the partial correlation coefficients ranged from 0.199 to 0.376 (P < 0.05). Log-transformed IL-1β and IL-6 levels entered the final regression model (standardized β were 0.422 and 0.461 respectively, P < 0.01).

Conclusions: Elevated plasma leptin concentration may be associated with increased systemic levels of inflammatory markers in AgP patients.

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References

Hotamisligil G, Peraldi P, Budavari A, Ellis R, White M, Spiegelman B . IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science. 1996; 271(5249):665-8. DOI: 10.1126/science.271.5249.665. View

Sun X, Meng H, Shi D, Xu L, Zhang L, Chen Z . Elevation of C-reactive protein and interleukin-6 in plasma of patients with aggressive periodontitis. J Periodontal Res. 2008; 44(3):311-6. DOI: 10.1111/j.1600-0765.2008.01131.x. View

Sarraf P, Frederich R, Turner E, Ma G, Jaskowiak N, Rivet 3rd D . Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J Exp Med. 1997; 185(1):171-5. PMC: 2196098. DOI: 10.1084/jem.185.1.171. View

Zhang F, Basinski M, Beals J, Briggs S, Churgay L, CLAWSON D . Crystal structure of the obese protein leptin-E100. Nature. 1997; 387(6629):206-9. DOI: 10.1038/387206a0. View

Faggioni R, Fantuzzi G, Fuller J, Dinarello C, Feingold K, Grunfeld C . IL-1 beta mediates leptin induction during inflammation. Am J Physiol. 1998; 274(1):R204-8. DOI: 10.1152/ajpregu.1998.274.1.R204. View

Tasaka Y, Yanagisawa K, Iwamoto Y . Human plasma leptin in obese subjects and diabetics. Endocr J. 1998; 44(5):671-6. DOI: 10.1507/endocrj.44.671. View

Leyva F, Godsland I, Ghatei M, Proudler A, Aldis S, Walton C . Hyperleptinemia as a component of a metabolic syndrome of cardiovascular risk. Arterioscler Thromb Vasc Biol. 1998; 18(6):928-33. DOI: 10.1161/01.atv.18.6.928. View

Ogawa Y, Masuzaki H, Hosoda K, Aizawa-Abe M, Suga J, Suda M . Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin. Diabetes. 1999; 48(9):1822-9. DOI: 10.2337/diabetes.48.9.1822. View

Karthikeyan B, Pradeep A . Gingival crevicular fluid and serum leptin: their relationship to periodontal health and disease. J Clin Periodontol. 2007; 34(6):467-72. DOI: 10.1111/j.1600-051X.2007.01078.x. View

10.

Seymour G, Ford P, Cullinan M, Leishman S, Yamazaki K . Relationship between periodontal infections and systemic disease. Clin Microbiol Infect. 2007; 13 Suppl 4:3-10. DOI: 10.1111/j.1469-0691.2007.01798.x. View

11.

Shi D, Meng H, Xu L, Zhang L, Chen Z, Feng X . Systemic inflammation markers in patients with aggressive periodontitis: a pilot study. J Periodontol. 2008; 79(12):2340-6. DOI: 10.1902/jop.2008.080192. View

12.

Kardesler L, Buduneli N, Cetinkalp S, Kinane D . Adipokines and inflammatory mediators after initial periodontal treatment in patients with type 2 diabetes and chronic periodontitis. J Periodontol. 2010; 81(1):24-33. DOI: 10.1902/jop.2009.090267. View

13.

Duarte P, Da Rocha M, Sampaio E, Mestnik M, Feres M, Figueiredo L . Serum levels of cytokines in subjects with generalized chronic and aggressive periodontitis before and after non-surgical periodontal therapy: a pilot study. J Periodontol. 2010; 81(7):1056-63. DOI: 10.1902/jop.2010.090732. View

14.

Shimada Y, Komatsu Y, Ikezawa-Suzuki I, Tai H, Sugita N, Yoshie H . The effect of periodontal treatment on serum leptin, interleukin-6, and C-reactive protein. J Periodontol. 2010; 81(8):1118-23. DOI: 10.1902/jop.2010.090741. View

15.

El-Awady A, Messer R, Gamal A, Sharawy M, Wenger K, Lapp C . Periodontal ligament fibroblasts sustain destructive immune modulators of chronic periodontitis. J Periodontol. 2010; 81(9):1324-35. DOI: 10.1902/jop.2010.100054. View

16.

Yuan T, Zhao W, Sun Q, Fu Y, Dong Y, Dong Y . Association between four adipokines and insulin sensitivity in patients with obesity, type 1 or type 2 diabetes mellitus, and in the general Chinese population. Chin Med J (Engl). 2010; 123(15):2018-22. View

17.

Gupta A, Gupta V . Metabolic syndrome: what are the risks for humans?. Biosci Trends. 2010; 4(5):204-12. View

18.

Jonsson D, Nebel D, Bratthall G, Nilsson B . The human periodontal ligament cell: a fibroblast-like cell acting as an immune cell. J Periodontal Res. 2010; 46(2):153-7. DOI: 10.1111/j.1600-0765.2010.01331.x. View

19.

Eickholz P, Siegelin Y, Scharf S, Schacher B, Oremek G, Sauer-Eppel H . Non-surgical periodontal therapy decreases serum elastase levels in aggressive but not in chronic periodontitis. J Clin Periodontol. 2013; 40(4):327-33. DOI: 10.1111/jcpe.12076. View

20.

Liu Y, Zhang X, Shi D, Cheng Z, Meng H . [Association between plasma leptin level and periodontal parameters in patients with aggressive periodontitis]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2013; 48(1):3-6. View