Formulation of Nanoliposomal Vitamin D3 for Potential Application in Beverage Fortification

Overview

Journal Adv Pharm Bull

Date 2015 Feb 12

PMID 25671191

Citations 28

Authors

Maryam Mohammadi

Babak Ghanbarzadeh

Hamed Hamishehkar

Affiliations

Soon will be listed here.

Abstract

Purpose: Vitamin D, a liposoluble vitamin has many benefits on health. Encapsulation of bioactives in lipid-based carrier systems like nanoliposomes preserves their native properties against oxidation over time along with providing its stable aqueous dispersion.

Methods: In the current study, vitamin D3 nanoliposomes were prepared using thin-film hydration-sonication method and fully characterized by different instrumental techniques.

Results: According to FTIR and DSC results, no interaction was observed between encapsulated nutraceutical and liposome constituents. The particle size and size distribution (Span value) were calculated 82-90 nm and 0.70-0.85, respectively. TEM analysis showed nano sized globular and bilayer vesicles. In all formations, the encapsulation efficiency of vitamin D3 was calculated more than 93%. Addition of cholesterol to lecithin bilayer increased the negative zeta potential from -29 to -43mV.

Conclusion: The results of this study concluded that the liposomal nanoparticles may be introduced as a suitable carrier for fortification of beverages with vitamin D3.

Citing Articles

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Mirzazadeh M, Bagheri H, Rasi F, Mirzazadeh N, Alam Z, Akhavan-Mahdavi S Int J Food Sci. 2024; 2024:9099501.

PMID: 39687482 PMC: 11649347. DOI: 10.1155/ijfo/9099501.

Recent Advances in the Use of Vitamin D Organic Nanocarriers for Drug Delivery.

Aggeletopoulou I, Kalafateli M, Geramoutsos G, Triantos C Biomolecules. 2024; 14(9).

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Development and characterization of active packaging system based on zein nanofibers mat incorporated with geraniol-loaded nanoliposomes.

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Nanoliposomal Encapsulation of Extract and Its Application in Jelly Formulation.

Zahedi Y, Shaddel R, Salamatian M, Szumny A Molecules. 2024; 29(12).

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Enhanced Stability of Oral Vitamin C Delivery: A Novel Large-Scale Method for Liposomes Production and Encapsulation through Dynamic High-Pressure Microfluidization.

Romano E, Palladino R, Cannavale M, Lamparelli E, Maglione B Nanomaterials (Basel). 2024; 14(6).

PMID: 38535664 PMC: 10975307. DOI: 10.3390/nano14060516.

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