Hepatocellular Carcinoma in Tyrosinemia Type 1 Without Clear Increase of AFP

Overview

Journal Pediatrics

Specialty Pediatrics

Date 2015 Feb 11

PMID 25667247

Citations 14

Authors

Willem G van Ginkel

Annette S H Gouw

Eric J van der Jagt

Koert P de Jong

Henkjan J Verkade

Francjan J van Spronsen

Affiliations

Soon will be listed here.

Abstract

Patients with hereditary tyrosinemia type 1 have an elevated risk of developing hepatocellular carcinoma, especially if initiation of treatment with 2-(2-nitro-4-trifluoro-methylbenzoyl)-1,3-cyclohexanedione is delayed. Hepatocellular carcinoma can usually be suspected when there are increased α1-fetoprotein levels and characteristic imaging features. The present case shows that a lack of a clear increase in α1-fetoprotein should still lead to consideration of liver transplantation when imaging features change.

Citing Articles

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