Behavioural Effects of the Benzodiazepine Receptor Partial Agonist RO 16-6028 in Mice

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1989 Jan 1

PMID 2566186

Citations 5

Authors

C Belzung

R Misslin

E Vogel

Affiliations

Soon will be listed here.

Abstract

The imidazo-diazepinone RO 16-6028 is a benzodiazepine receptor partial agonist which exhibits some anti-conflict effects in the two-chambered light/dark test without significantly affecting the behaviour of mice confronted with the staircase test. In addition, this drug slightly reduced locomotion and more markedly rearing in a free exploration procedure. These results indicate that RO 16-6028 appears to produce some anxiolytic and sedative properties like full agonists, but with weaker magnitude. This could be related to the benzodiazepine partial agonistic profile of the compound.

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