Overexpression of LIMK1 Promotes Tumor Growth and Metastasis in Gastric Cancer

Overview

Journal Biomed Pharmacother

Specialties Biology
General Medicine
Pharmacology

Date 2015 Feb 10

PMID 25661344

Citations 22

Authors

Tiangeng You

Wei Gao

Jun Wei

Xiaoli Jin

Zhongxin Zhao

Congjun Wang

Yang Li

Affiliations

Soon will be listed here.

Abstract

Gastric cancer is the second-leading cause of cancer death in Asia. Despite improvement of therapies, the outcome in patients remains extremely poor because of metastasis. In the present study, we found that LIMK1 is overexpressed in gastric cancer, and its expression level correlate with tumor size, lymph node metastasis and TNM stage. Knockdown of LIMK1 expression could inhibit cell proliferation, migration and invasion in vitro, as well as suppress the activation of FAK/paxillin pathway. Moreover, knockdown of LIMK1 expression retarded tumor growth and peritoneal ametastasis in vivo. This highlights that LIMK1 might be used as a potential target in the treatment of gastric cancer.

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