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N-methyl-D-aspartate Antagonists: Ready for Clinical Trial in Brain Ischemia?

Overview
Journal Ann Neurol
Specialty Neurology
Date 1989 Apr 1
PMID 2565699
Citations 28
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Abstract

Antagonists of the N-methyl-D-aspartate (NMDA) subclass of glutamate receptors may offer a new approach for the treatment of ischemic brain injury. This strategy is supported by a well-developed scientific foundation and encouraging results in a variety of in vivo and in vitro experimental models. Several specific antagonists, including MK-801, dextrorphan, dextromethorphan, and ketamine, have already been used at low doses in humans for other indications and are potential candidates for Phase I clinical trials.

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