Neuroleptic-induced Akathisia: a Review

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1989 Jan 1

PMID 2565586

Citations 18

Authors

L A Adler

B Angrist

S Reiter

J Rotrosen

Affiliations

Soon will be listed here.

Abstract

Neuroleptic-induced akathisia (NIA) is a relatively common side effect of neuroleptics, in which patients complain of a subjective sense of restlessness usually referable to the legs and have characteristic motor movements. This paper will review: 1) history of spontaneously occurring syndromes of pathologic restlessness and NIA, 2) the clinical significance of NIA, 3) issues concerning the diagnosis and quantification of NIA, 4) treatments of NIA and 5) possible future directions for research in this area. Special attention will be paid to newer treatments for this syndrome, specifically beta-blockers.

Citing Articles

Revisiting Antipsychotic-induced Akathisia: Current Issues and Prospective Challenges.

Salem H, Nagpal C, Pigott T, Teixeira A Curr Neuropharmacol. 2016; 15(5):789-798.

PMID: 27928948 PMC: 5771055. DOI: 10.2174/1570159X14666161208153644.

Mirtazapine Induced Akathisia: Understanding a Complex Mechanism.

Raveendranathan D, Swaminath G Indian J Psychol Med. 2015; 37(4):474-5.

PMID: 26702190 PMC: 4676224. DOI: 10.4103/0253-7176.168615.

Antipsychotic-induced movement disorders: evaluation and treatment.

Mathews M, Gratz S, Adetunji B, George V, Mathews M, Basil B Psychiatry (Edgmont). 2010; 2(3):36-41.

PMID: 21179628 PMC: 3004713.

Relapse and rehospitalisation rates in patients with schizophrenia: effects of second generation antipsychotics.

Csernansky J, Schuchart E CNS Drugs. 2002; 16(7):473-84.

PMID: 12056922 DOI: 10.2165/00023210-200216070-00004.

Antipsychotic-Induced movement disorders in the elderly: epidemiology and treatment recommendations.

Caligiuri M, Jeste D, Lacro J Drugs Aging. 2001; 17(5):363-84.

PMID: 11190417 DOI: 10.2165/00002512-200017050-00004.

References

Blom S, EKBOM K . Comparison between akathisia developing on treatment with phenothiazine derivatives and the restless legs syndrome. Acta Med Scand. 1961; 170:689-94. DOI: 10.1111/j.0954-6820.1961.tb00286.x. View

Adler L, Angrist B, Peselow E, Corwin J, Rotrosen J . Efficacy of propranolol in neuroleptic-induced akathesia. J Clin Psychopharmacol. 1985; 5(3):164-6. View

CRANE G . Pseudoparkinsonism and tardive dyskinesia. Arch Neurol. 1972; 27(5):426-30. DOI: 10.1001/archneur.1972.00490170058008. View

Braude W, Barnes T, Gore S . Clinical characteristics of akathisia. A systematic investigation of acute psychiatric inpatient admissions. Br J Psychiatry. 1983; 143:139-50. DOI: 10.1192/bjp.143.2.139. View

Adler L, Angrist B, Peselow E, Corwin J, Maslansky R, Rotrosen J . A controlled assessment of propranolol in the treatment of neuroleptic-induced akathisia. Br J Psychiatry. 1986; 149:42-5. DOI: 10.1192/bjp.149.1.42. View

Bartels M, Heide K, Mann K, Schied H . Treatment of akathisia with lorazepam. An open clinical trial. Pharmacopsychiatry. 1987; 20(2):51-3. DOI: 10.1055/s-2007-1017074. View

Charney D, Sternberg D, KLEBER H, Heninger G, Redmond Jr D . The clinical use of clonidine in abrupt withdrawal from methadone. Effects on blood pressure and specific signs and symptoms. Arch Gen Psychiatry. 1981; 38(11):1273-7. DOI: 10.1001/archpsyc.1981.01780360089010. View

Braude W, Barnes T . Late-onset akathisia--an indicant of covert dyskinesia: two case reports. Am J Psychiatry. 1983; 140(5):611-2. DOI: 10.1176/ajp.140.5.611. View

Cruickshank J . The clinical importance of cardioselectivity and lipophilicity in beta blockers. Am Heart J. 1980; 100(2):160-78. DOI: 10.1016/0002-8703(80)90112-x. View

10.

Chouinard G, Annable L, Nestoros J . Factors related to tardive dyskinesia. Am J Psychiatry. 1979; 136(1):79-82. DOI: 10.1176/ajp.136.1.79. View

11.

Brown K, Glen S, White T . Low serum iron status and akathisia. Lancet. 1987; 1(8544):1234-6. DOI: 10.1016/s0140-6736(87)92687-0. View