The Assessment of the Relationship Between Personality, the Presence of the 5HTT and MAO-A Polymorphisms, and the Severity of Climacteric and Depressive Symptoms in Postmenopausal Women

Overview

Journal Arch Womens Ment Health

Publisher Springer

Specialties Gynecology & Obstetrics
Psychiatry
Psychology

Date 2015 Feb 7

PMID 25655492

Citations 9

Authors

Anna Jurczak

Malgorzata Szkup

Sylwia Wieder-Huszla

Anna Grzywacz

Agnieszka Samochowiec

Beata Karakiewicz

Jerzy Samochowiec

Elzbieta Grochans

Affiliations

Soon will be listed here.

Abstract

The purpose of this study is to determine the relationship between personality, the serotonin transporter (5HTT) and monoamine oxidase A (MAO-A) polymorphisms and the severity of climacteric and depressive symptoms in postmenopausal women. The study involved 272 healthy postmenopausal women from Poland. This survey-based study was performed using the following: the Beck Depression Inventory for depressive symptoms, the Blatt-Kupperman Menopausal Index and the Neuroticism-Extroversion-Openness-Five Factor Inventory for personality. A polymerase chain reaction was employed to identify the DNA polymorphisms. The women were aged 55.4 ± 5.5 years on average. Significant correlations were proved between the allele frequency of the 30-bp variable-number tandem repeat (VNTR) polymorphism in the MAO-A promoter region and the incidence of depressive symptoms in the women analysed (p ≤ 0.05), as well as between the severity of climacteric symptoms in the postmenopausal women and the allele frequency of the polymorphism in the 5HTT gene (the 5HTT 's' variant) (p ≤ 0.05). There was a significant correlation between the severity of climacteric and depressive symptoms (p < 0.001). (1) The severity of climacteric and depressive symptoms depends on personality traits. (2) Personality traits are biologically determined, and the level of their expression is associated with the 5HTT polymorphism. (3) Identification of homogeneous groups of women having predispositions to depressive and severe climacteric symptoms may help to implement early prevention programmes for this group of recipients.

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