Influence of Grape Seed Extract and Zinc Containing Multivitamin-mineral Nutritional Food Supplement on Lipid Profile in Normal and Diet-induced Hypercholesterolemic Rats

Overview

Journal J Clin Diagn Res

Specialty General Medicine

Date 2015 Feb 6

PMID 25653967

Citations 1

Authors

Shakta Mani Satyam

Laxminarayana Kurady Bairy

Rajadurai Pirasanthan

Affiliations

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Abstract

Background: Zincovit tablet is combination of grape seed extract and zinc containing multivitamin-mineral nutritional food supplement.

Aims: To investigate the influence of single combined formulation of grape seed extract and zinc containing multivitamin-mineral nutritional food supplement tablets (Zincovit) on lipid profile in normal and diet-induced hypercholesterolemic rats.

Materials And Methods: Anti-hyperlipidemic activity of combined formulation of grape seed extract and Zincovit tablets doses ranged from 40 to 160 mg/kg, p.o. was evaluated in normal and diet-induced hypercholesterolemic rats.

Results: Hypercholesterolemic animals treated with combined formulation of grape seed extract and Zincovit tablets (nutritional food supplement) at 40, 80 and 160 mg/kg exhibited drastic decrease in serum triglycerides, total cholesterol, LDL-C, VLDL-C and rise of HDL-C in comparison to hypercholesterolemic control group animals. The anti-hyperlipidemic effect of single combined formulation of grape seed extract and Zincovit tablet was comparable with the standard drug atorvastatin treated animals and the variations were statistically non-significant. There was no significant impact of combined formulation of grape seed extract and Zincovit tablets on lipid profile among normal animals in comparison with normal control group.

Conclusion: The present study demonstrated that the single combined formulation of grape seed extract and Zincovit tablet is the potential functional nutritional food supplements that could offer a novel therapeutic opportunity against diet-induced hypercholesterolemia in Wistar rats.

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