New Approaches to Radiation Protection

Overview

Journal Front Oncol

Specialty Oncology

Date 2015 Feb 6

PMID 25653923

Citations 55

Authors

Eliot M Rosen

Regina Day

Vijay K Singh

Affiliations

Soon will be listed here.

Abstract

Radioprotectors are compounds that protect against radiation injury when given prior to radiation exposure. Mitigators can protect against radiation injury when given after exposure but before symptoms appear. Radioprotectors and mitigators can potentially improve the outcomes of radiotherapy for cancer treatment by allowing higher doses of radiation and/or reduced damage to normal tissues. Such compounds can also potentially counteract the effects of accidental exposure to radiation or deliberate exposure (e.g., nuclear reactor meltdown, dirty bomb, or nuclear bomb explosion); hence they are called radiation countermeasures. Here, we will review the general principles of radiation injury and protection and describe selected examples of radioprotectors/mitigators ranging from small-molecules to proteins to cell-based treatments. We will emphasize agents that are in more advanced stages of development.

Citing Articles

Molecular Insights into Radiation Effects and Protective Mechanisms: A Focus on Cellular Damage and Radioprotectors.

Ibanez B, Melero A, Montoro A, San Onofre N, Soriano J Curr Issues Mol Biol. 2024; 46(11):12718-12732.

PMID: 39590349 PMC: 11592695. DOI: 10.3390/cimb46110755.

Thrombopoietin mimetic therapy alleviates radiation-induced bone marrow vascular injury in a bone marrow transplant mouse model.

Ghimire H, Madabushi S, Vercellino J, Brooks J, Zuro D, Lim J Front Oncol. 2024; 14:1414488.

PMID: 39450249 PMC: 11499237. DOI: 10.3389/fonc.2024.1414488.

Protective alleles and precision healthcare in crewed spaceflight.

Rutter L, MacKay M, Cope H, Szewczyk N, Kim J, Overbey E Nat Commun. 2024; 15(1):6158.

PMID: 39039045 PMC: 11263583. DOI: 10.1038/s41467-024-49423-6.

Health Effects of Ionizing Radiation on the Human Body.

Talapko J, Talapko D, Katalinic D, Kotris I, Eric I, Belic D Medicina (Kaunas). 2024; 60(4).

PMID: 38674299 PMC: 11052428. DOI: 10.3390/medicina60040653.

Mathematical complexities in radionuclide metabolic modelling: a review of ordinary differential equation kinetics solvers in biokinetic modelling.

Mate-Kole E, Dewji S J Radiol Prot. 2024; 44(2).

PMID: 38324906 PMC: 11214694. DOI: 10.1088/1361-6498/ad270d.

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