Bacterial Infections in Childhood: A Risk Factor for Gastrointestinal and Other Diseases?
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Background: There is evidence for post-infectious irritable bowel syndrome (PI-IBS) in adults, but little is known about PI-IBS in children. The nationwide representative German Health Interview and Examination Survey for Children and Adolescents (KiGGS) assessed children's health.
Objective And Methods: We identified 643 children (50.1% males) in the KiGGS cohort (N = 15,878, 51% males) with a history of Salmonella infection. The number was validated comparing this group with the known infection statistics from the Robert Koch-Institute registry. We compared this group to the remaining KiGGS cohort (n = 12,951) with respect to sociodemographic characteristics, pain and quality of life. To check for specificity, we repeated the comparisons with a group with a history of scarlet fever.
Results: Infection statistics predicted 504 cases of Salmonella infection in the KiGGS cohort, indicating high validity of the data. In children between 3 and 10 years with a history of Salmonella infection, significantly more abdominal pain (31.7% versus 21.9%, p < 0.001) and headache (27.2% versus 15.1%, p < 0.001) were reported. This group showed lower quality of life (p < 0.001). Comparison to a group of scarlet fever-infected children revealed poor specificity of the data.
Conclusion: Differences found between children with and without Salmonella infection reveal the role of gastrointestinal infection in the development of post-infectious abdominal problems, but poor specificity may point toward a psychosocial ("somatization") rather than a Salmonella-specific mechanism.
Ness V, Humberg C, Lucius F, Eidt L, Berger T, Classen M Children (Basel). 2024; 11(7).
PMID: 39062295 PMC: 11276134. DOI: 10.3390/children11070846.
Choung R, Saito Y, Schleck C, Harmsen W, Zinsmeister A, Murray J Mayo Clin Proc. 2021; 96(3):563-576.
PMID: 33673910 PMC: 8127806. DOI: 10.1016/j.mayocp.2020.08.043.
Ingram J, Tursi S, Zhang T, Guo W, Yin C, Wynosky-Dolfi M J Immunol. 2018; 200(10):3626-3634.
PMID: 29654208 PMC: 6034694. DOI: 10.4049/jimmunol.1701386.
Interferon-γ in Salmonella pathogenesis: New tricks for an old dog.
Ingram J, Brodsky I, Balachandran S Cytokine. 2016; 98:27-32.
PMID: 27773552 PMC: 5398957. DOI: 10.1016/j.cyto.2016.10.009.