Changes in Serum Ghrelin Level in Relation to Meal-time in Patients with Functional Dyspepsia

Overview

Journal United European Gastroenterol J

Publisher Wiley

Specialty Gastroenterology

Date 2015 Feb 6

PMID 25653854

Citations 10

Authors

Mh Kazemi

A Eshraghian

L Hamidpour

Sa Taghavi

Affiliations

Soon will be listed here.

Abstract

Background: Ghrelin is a peptide hormone that is involved in gastrointestinal motility and secretion; and therefore, may play a role in functional dyspepsia.

Objectives: To compare the change of serum ghrelin level in relation to meal-time, between patients with functional dyspepsia and a control group.

Materials And Methods: In a cross-sectional study, 18 subjects with functional dyspepsia according to the Rome III criteria were enrolled in our study. Blood samples were collected five times: 30 minutes (min) before a standard breakfast; at the time as serving breakfast; and 30, 60 and 90 min after breakfast. Serum ghrelin concentration was measured in these patients and compared with eight normal individuals, as controls.

Results: The serum ghrelin level 30 minutes after breakfast was significantly higher in dyspepsia patients, compared to controls (751 ± 171.84 pg/ml versus 576.9 ± 195.62 pg/ml, p = 0.033). Although patients had a higher mean serum ghrelin level 30 minutes before, exactly at the time of serving breakfast and 60 min after breakfast there was no statistically significant difference between patients and controls. The shape of the curve was also different between the two groups, from 30 min until 90 min after breakfast, which is the time that most dyspeptic symptoms usually occur, although this difference was not significant (p > 0.05).

Conclusion: The significantly different ghrelin levels between dyspeptic patients and the normal population showed that ghrelin may have an important role in inducing symptoms, in functional dyspeptic patients.

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References

Tack J, Talley N, Camilleri M, Holtmann G, Hu P, Malagelada J . Functional gastroduodenal disorders. Gastroenterology. 2006; 130(5):1466-79. DOI: 10.1053/j.gastro.2005.11.059. View

Yakabi K, Kawashima J, Kato S . Ghrelin and gastric acid secretion. World J Gastroenterol. 2008; 14(41):6334-8. PMC: 2766114. DOI: 10.3748/wjg.14.6334. View

Kojima M, Kangawa K . Ghrelin: structure and function. Physiol Rev. 2005; 85(2):495-522. DOI: 10.1152/physrev.00012.2004. View

Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K . Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999; 402(6762):656-60. DOI: 10.1038/45230. View

Kim Y, Lee J, Lee T, Cho J, Kim J, Kim W . Plasma levels of acylated ghrelin in patients with functional dyspepsia. World J Gastroenterol. 2012; 18(18):2231-7. PMC: 3351774. DOI: 10.3748/wjg.v18.i18.2231. View

Veldhuyzen van Zanten S, Flook N, Chiba N, Armstrong D, Barkun A, Bradette M . An evidence-based approach to the management of uninvestigated dyspepsia in the era of Helicobacter pylori. Canadian Dyspepsia Working Group. CMAJ. 2000; 162(12 Suppl):S3-23. PMC: 1232536. View

Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal M, Suganuma T . Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology. 2000; 141(11):4255-61. DOI: 10.1210/endo.141.11.7757. View

Shimada M, Date Y, Mondal M, Toshinai K, Shimbara T, Fukunaga K . Somatostatin suppresses ghrelin secretion from the rat stomach. Biochem Biophys Res Commun. 2003; 302(3):520-5. DOI: 10.1016/s0006-291x(03)00178-5. View

Bilgin H, Tumer C, Diken H, Kelle M, Sermet A . Role of ghrelin in the regulation of gastric acid secretion involving nitrergic mechanisms in rats. Physiol Res. 2007; 57(4):563-568. DOI: 10.33549/physiolres.931234. View

10.

Suzuki H, Moayyedi P . Helicobacter pylori infection in functional dyspepsia. Nat Rev Gastroenterol Hepatol. 2013; 10(3):168-74. DOI: 10.1038/nrgastro.2013.9. View

11.

Takamori K, Mizuta Y, Takeshima F, Akazawa Y, Isomoto H, Ohnita K . Relation among plasma ghrelin level, gastric emptying, and psychologic condition in patients with functional dyspepsia. J Clin Gastroenterol. 2007; 41(5):477-83. DOI: 10.1097/01.mcg.0000225614.94470.47. View

12.

Ukkola O, Ravussin E, Jacobson P, Perusse L, Rankinen T, Tschop M . Role of ghrelin polymorphisms in obesity based on three different studies. Obes Res. 2002; 10(8):782-91. DOI: 10.1038/oby.2002.106. View

13.

Natalucci G, Riedl S, Gleiss A, Zidek T, Frisch H . Spontaneous 24-h ghrelin secretion pattern in fasting subjects: maintenance of a meal-related pattern. Eur J Endocrinol. 2005; 152(6):845-50. DOI: 10.1530/eje.1.01919. View

14.

De Smet B, Mitselos A, Depoortere I . Motilin and ghrelin as prokinetic drug targets. Pharmacol Ther. 2009; 123(2):207-23. DOI: 10.1016/j.pharmthera.2009.04.004. View

15.

Ohno T, Mochiki E, Kuwano H . The roles of motilin and ghrelin in gastrointestinal motility. Int J Pept. 2010; 2010. PMC: 2925306. DOI: 10.1155/2010/820794. View

16.

Lee K, Cha D, Cheon S, Yeo M, Cho S . Plasma ghrelin levels and their relationship with gastric emptying in patients with dysmotility-like functional dyspepsia. Digestion. 2009; 80(1):58-63. DOI: 10.1159/000215389. View

17.

Akamizu T, Iwakura H, Ariyasu H, Kangawa K . Ghrelin and functional dyspepsia. Int J Pept. 2010; 2010. PMC: 2915802. DOI: 10.1155/2010/548457. View

18.

Tack J, Talley N . Functional dyspepsia--symptoms, definitions and validity of the Rome III criteria. Nat Rev Gastroenterol Hepatol. 2013; 10(3):134-41. DOI: 10.1038/nrgastro.2013.14. View

19.

Flanagan D, Evans M, Monsod T, Rife F, Heptulla R, Tamborlane W . The influence of insulin on circulating ghrelin. Am J Physiol Endocrinol Metab. 2003; 284(2):E313-6. DOI: 10.1152/ajpendo.00569.2001. View

20.

Stec-Michalska K, Malicki S, Michalski B, Peczek L, Wisniewska-Jarosinska M, Nawrot B . Gastric ghrelin in relation to gender, stomach topography and Helicobacter pylori in dyspeptic patients. World J Gastroenterol. 2009; 15(43):5409-17. PMC: 2778096. DOI: 10.3748/wjg.15.5409. View