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CD40L-adjuvanted DNA/modified Vaccinia Virus Ankara Simian Immunodeficiency Virus (SIV) Vaccine Enhances Protection Against Neutralization-resistant Mucosal SIV Infection

Overview
Journal J Virol
Publisher American Society for Microbiology
Date 2015 Feb 6
PMID 25653428
Citations 26
Authors
Suefen Kwa
Shanmugalakshmi Sadagopal
Xiaoying Shen
Jung Joo Hong
Sailaja Gangadhara
Rahul Basu
Blandine Victor
Smita S Iyer
Celia C LaBranche
David C Montefiori
Georgia D Tomaras
Francois Villinger
Bernard Moss
Pamela A Kozlowski
Rama Rao Amara
Affiliations
Soon will be listed here.
Abstract

Here, we show that a CD40L-adjuvanted DNA/modified vaccinia virus Ankara (MVA) simian immunodeficiency virus (SIV) vaccine enhances protection against a pathogenic neutralization-resistant mucosal SIV infection, improves long-term viral control, and prevents AIDS. Analyses of serum IgG antibodies to linear peptides of SIV Env revealed a strong response to V2, with targeting of fewer epitopes in the immunodominant region of gp41 (gp41-ID) and the V1 region as a correlate for enhanced protection. Greater expansion of antiviral CD8 T cells in the gut correlated with long-term viral control.

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