Clinical Significance of Circulating Tumor Cells in Peripheral Blood of Patients with Esophageal Squamous Cell Carcinoma

Overview

Journal Ann Surg Oncol

Publisher Springer

Specialty Oncology

Date 2015 Feb 6

PMID 25652049

Citations 26

Authors

Daisuke Matsushita

Yoshikazu Uenosono

Takaaki Arigami

Shigehiro Yanagita

Yuka Nishizono

Takahiko Hagihara

Munetsugu Hirata

Naoto Haraguchi

Hideo Arima

Yuko Kijima

Hiroshi Kurahara

Kosei Maemura

Hiroshi Okumura

Sumiya Ishigami

Shoji Natsugoe

Affiliations

Soon will be listed here.

Abstract

Background: Esophageal squamous cell carcinoma is an aggressive gastrointestinal tract cancer. To date, the presence of circulating tumor cells (CTC) has been reported as a prognostic factor in peripheral blood from patients with gastrointestinal cancers.

Methods: The CellSearch system was used to isolate and enumerate CTCs. A total of 90 patients with esophageal squamous cell carcinoma who received chemotherapy or chemoradiotherapy were enrolled. Peripheral blood specimens were collected before and after treatments.

Results: At baseline analysis, CTCs were detected in 25 patients (27.8 %). Overall survival was significantly shorter in patients with than without CTCs. Follow-up blood specimens were obtained from 71 patients. Partial response, stable disease, and progressive disease after treatment were seen in 32, 12, and 27 patients, respectively. CTC positivity after treatment in the progressive disease group (40.7 %) was significantly higher than that of the partial response group (6.3 %). Patients with a change in CTC status from positive to negative had a good prognosis as well as patients without baseline CTCs.

Conclusions: Evaluation of CTCs may be a promising indicator for predicting tumor prognosis and the clinical efficacy of chemotherapy or chemoradiation therapy in patients with esophageal squamous cell carcinoma.

Citing Articles

Multigene Profiling of Circulating Tumor Cells in Esophageal Squamous Cell Carcinoma Identifies Prognostic Cancer Driver Genes Associated with Epithelial-Mesenchymal-Transition Progression and Chemoresistance.

Tan Z, Ko J, Yu V, Lam K, Kwong D, Wong I Cancers (Basel). 2023; 15(22).

PMID: 38001588 PMC: 10670643. DOI: 10.3390/cancers15225329.

Circulating Tumor Cell Enumeration for Serial Monitoring of Treatment Outcomes for Locally Advanced Esophageal Squamous Cell Carcinoma.

Ko J, Lam K, Kwong D, Wong I, Chan F, Wong C Cancers (Basel). 2023; 15(3).

PMID: 36765790 PMC: 9913330. DOI: 10.3390/cancers15030832.

Liquid Biopsy in Squamous Cell Carcinoma of the Esophagus and of the Head and Neck.

Iacob R, Mandea M, Iacob S, Pietrosanu C, Paul D, Hainarosie R Front Med (Lausanne). 2022; 9:827297.

PMID: 35572996 PMC: 9098838. DOI: 10.3389/fmed.2022.827297.

Circulating Tumor Cells in Esophageal Squamous Cell Carcinoma - Mini Review.

Shi Y, Ge X, Ju M, Zhang Y, Di X, Liang L Cancer Manag Res. 2021; 13:8355-8365.

PMID: 34764697 PMC: 8577339. DOI: 10.2147/CMAR.S337489.

Cancer associated macrophage-like cells and prognosis of esophageal cancer after chemoradiation therapy.

Gironda D, Adams D, He J, Xu T, Gao H, Qiao Y J Transl Med. 2020; 18(1):413.

PMID: 33148307 PMC: 7640696. DOI: 10.1186/s12967-020-02563-x.

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