The Genetic Landscape of Cardiomyopathy and Its Role in Heart Failure

Overview

Journal Cell Metab

Publisher Cell Press

Specialties Cell Biology
Endocrinology

Date 2015 Feb 5

PMID 25651172

Citations 71

Authors

Elizabeth M McNally

David Y Barefield

Megan J Puckelwartz

Affiliations

Soon will be listed here.

Abstract

Heart failure is highly influenced by heritability, and nearly 100 genes link to familial cardiomyopathy. Despite the marked genetic diversity that underlies these complex cardiovascular phenotypes, several key genes and pathways have emerged. Hypertrophic cardiomyopathy is characterized by increased contractility and a greater energetic cost of cardiac output. Dilated cardiomyopathy is often triggered by mutations that disrupt the giant protein titin. The energetic consequences of these mutations offer molecular targets and opportunities for new drug development and gene correction therapies.

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