Do We Need a New Definition of Sepsis?

Overview

Journal Intensive Care Med

Specialty Critical Care

Date 2015 Feb 4

PMID 25643905

Citations 17

Authors

Manu Shankar-Hari

Clifford S Deutschman

Mervyn Singer

Affiliations

Soon will be listed here.

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References

Adhikari N, Fowler R, Bhagwanjee S, Rubenfeld G . Critical care and the global burden of critical illness in adults. Lancet. 2010; 376(9749):1339-46. PMC: 7136988. DOI: 10.1016/S0140-6736(10)60446-1. View

Czura C . "Merinoff symposium 2010: sepsis"-speaking with one voice. Mol Med. 2011; 17(1-2):2-3. PMC: 3022986. DOI: 10.2119/molmed.2010.00001.commentary. View

Gaieski D, Edwards J, Kallan M, Carr B . Benchmarking the incidence and mortality of severe sepsis in the United States. Crit Care Med. 2013; 41(5):1167-74. DOI: 10.1097/CCM.0b013e31827c09f8. View

Yealy D, Kellum J, Huang D, Barnato A, Weissfeld L, Pike F . A randomized trial of protocol-based care for early septic shock. N Engl J Med. 2014; 370(18):1683-93. PMC: 4101700. DOI: 10.1056/NEJMoa1401602. View

Levy M, Fink M, Marshall J, Abraham E, Angus D, Cook D . 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med. 2003; 29(4):530-8. DOI: 10.1007/s00134-003-1662-x. View

Rhee C, Gohil S, Klompas M . Regulatory mandates for sepsis care--reasons for caution. N Engl J Med. 2014; 370(18):1673-6. PMC: 4718398. DOI: 10.1056/NEJMp1400276. View

Peake S, Delaney A, Bailey M, Bellomo R, Cameron P, Cooper D . Goal-directed resuscitation for patients with early septic shock. N Engl J Med. 2014; 371(16):1496-506. DOI: 10.1056/NEJMoa1404380. View

Hotchkiss R, Monneret G, Payen D . Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol. 2013; 13(12):862-74. PMC: 4077177. DOI: 10.1038/nri3552. View

Nathan C, Cars O . Antibiotic resistance--problems, progress, and prospects. N Engl J Med. 2014; 371(19):1761-3. DOI: 10.1056/NEJMp1408040. View

10.

Bone R, Sibbald W, Sprung C . The ACCP-SCCM consensus conference on sepsis and organ failure. Chest. 1992; 101(6):1481-3. DOI: 10.1378/chest.101.6.1481. View

11.

Xiao W, Mindrinos M, Seok J, Cuschieri J, Cuenca A, Gao H . A genomic storm in critically injured humans. J Exp Med. 2011; 208(13):2581-90. PMC: 3244029. DOI: 10.1084/jem.20111354. View

12.

Clermont G, Angus D, Linde-Zwirble W, Griffin M, Fine M, Pinsky M . Does acute organ dysfunction predict patient-centered outcomes?. Chest. 2002; 121(6):1963-71. DOI: 10.1378/chest.121.6.1963. View

13.

Ferrer R, Martin-Loeches I, Phillips G, Osborn T, Townsend S, Dellinger R . Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program. Crit Care Med. 2014; 42(8):1749-55. DOI: 10.1097/CCM.0000000000000330. View

14.

Kaukonen K, Bailey M, Suzuki S, Pilcher D, Bellomo R . Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012. JAMA. 2014; 311(13):1308-16. DOI: 10.1001/jama.2014.2637. View

15.

Kumar A, Roberts D, Wood K, Light B, Parrillo J, Sharma S . Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006; 34(6):1589-96. DOI: 10.1097/01.CCM.0000217961.75225.E9. View