Memory Timeline: Brain ERP C250 (not P300) is an Early Biomarker of Short-term Storage

Overview

Journal Brain Res

Specialty Neurology

Date 2015 Feb 3

PMID 25641043

Citations 2

Authors

Robert M Chapman

Margaret N Gardner

Mark Mapstone

Haley M Dupree

Inga M Antonsdottir

Affiliations

Soon will be listed here.

Abstract

Brain event-related potentials (ERPs) offer a quantitative link between neurophysiological activity and cognitive performance. ERPs were measured while young adults performed a task that required storing a relevant stimulus in short-term memory. Using principal components analysis, ERP component C250 (maximum at 250 ms post-stimulus) was extracted from a set of ERPs that were separately averaged for various task conditions, including stimulus relevancy and stimulus sequence within a trial. C250 was more positive in response to task-specific stimuli that were successfully stored in short-term memory. This relationship between C250 and short-term memory storage of a stimulus was confirmed by a memory probe recall test where the behavioral recall of a stimulus was highly correlated with its C250 amplitude. ERP component P300 (and its subcomponents of P3a and P3b, which are commonly thought to represent memory operations) did not show a pattern of activation reflective of storing task-relevant stimuli. C250 precedes the P300, indicating that initial short-term memory storage may occur earlier than previously believed. Additionally, because C250 is so strongly predictive of a stimulus being stored in short-term memory, C250 may provide a strong index of early memory operations.

Citing Articles

Temporospatial components of brain ERPs as biomarkers for Alzheimer's disease.

Chapman R, Gardner M, Klorman R, Mapstone M, Porsteinsson A, Antonsdottir I Alzheimers Dement (Amst). 2018; 10:604-614.

PMID: 30417070 PMC: 6215980. DOI: 10.1016/j.dadm.2018.08.002.

ERP C250 shows the elderly (cognitively normal, Alzheimer's disease) store more stimuli in short-term memory than Young Adults do.

Chapman R, Gardner M, Mapstone M, Klorman R, Porsteinsson A, Dupree H Clin Neurophysiol. 2016; 127(6):2423-35.

PMID: 27178862 PMC: 4959798. DOI: 10.1016/j.clinph.2016.03.006.

References

Picton T, Bentin S, Berg P, Donchin E, Hillyard S, Johnson Jr R . Guidelines for using human event-related potentials to study cognition: recording standards and publication criteria. Psychophysiology. 2000; 37(2):127-52. View

Friedman D . Event-related brain potential investigations of memory and aging. Biol Psychol. 2000; 54(1-3):175-206. DOI: 10.1016/s0301-0511(00)00056-9. View

Sommer W, Schweinberger S . Age-related slowing in face and name recognition: evidence from event-related brain potentials. Psychol Aging. 2002; 17(1):140-60. DOI: 10.1037//0882-7974.17.1.140. View

Missonnier P, Leonards U, Gold G, Palix J, Ibanez V, Giannakopoulos P . A new electrophysiological index for working memory load in humans. Neuroreport. 2003; 14(11):1451-5. DOI: 10.1097/00001756-200308060-00009. View

Polich J . Clinical application of the P300 event-related brain potential. Phys Med Rehabil Clin N Am. 2004; 15(1):133-61. DOI: 10.1016/s1047-9651(03)00109-8. View

Missonnier P, Gold G, Leonards U, Costa-Fazio L, Michel J, Ibanez V . Aging and working memory: early deficits in EEG activation of posterior cortical areas. J Neural Transm (Vienna). 2004; 111(9):1141-54. DOI: 10.1007/s00702-004-0159-2. View

Ruchkin D, Grafman J, Cameron K, Berndt R . Working memory retention systems: a state of activated long-term memory. Behav Brain Sci. 2004; 26(6):709-28. DOI: 10.1017/s0140525x03000165. View

Trenner M, Schweinberger S, Jentzsch I, Sommer W . Face repetition effects in direct and indirect tasks: an event-related brain potentials study. Brain Res Cogn Brain Res. 2004; 21(3):388-400. DOI: 10.1016/j.cogbrainres.2004.06.017. View

Begleiter H, Porjesz B . Evoked brain potentials as indicators of decision-making. Science. 1975; 187(4178):754-5. View

10.

Chapman R, McCrary J, Chapman J, BRAGDON H . Brain responses related to semantic meaning. Brain Lang. 1978; 5(2):195-205. DOI: 10.1016/0093-934x(78)90018-4. View

11.

Friedman D, Vaughan Jr H, Erlenmeyer-Kimling L . Stimulus and response related components of the late positive complex in visual discrimination tasks. Electroencephalogr Clin Neurophysiol. 1978; 45(3):319-30. DOI: 10.1016/0013-4694(78)90184-0. View

12.

Chapman R, McCrary J, Chapman J . Short-term memory: the "storage" component of human brain responses predicts recall. Science. 1978; 202(4373):1211-4. DOI: 10.1126/science.725596. View

13.

Chapman R, McCrary J, Chapman J . Memory processes and evoked potentials. Can J Psychol. 1981; 35(2):201-12. DOI: 10.1037/h0081152. View

14.

Ruchkin D, Johnson Jr R, Canoune H, Ritter W . Short-term memory storage and retention: an event-related brain potential study. Electroencephalogr Clin Neurophysiol. 1990; 76(5):419-39. DOI: 10.1016/0013-4694(90)90096-3. View

15.

Begleiter H, Porjesz B, Wang W . A neurophysiologic correlate of visual short-term memory in humans. Electroencephalogr Clin Neurophysiol. 1993; 87(1):46-53. DOI: 10.1016/0013-4694(93)90173-s. View

16.

Chapman R, McCrary J . EP component identification and measurement by principal components analysis. Brain Cogn. 1995; 27(3):288-310. DOI: 10.1006/brcg.1995.1024. View

17.

Zhang X, Begleiter H, Porjesz B, Litke A . Visual object priming differs from visual word priming: an ERP study. Electroencephalogr Clin Neurophysiol. 1997; 102(3):200-15. DOI: 10.1016/s0013-4694(96)95172-3. View

18.

Dunn B, Dunn D, Languis M, Andrews D . The relation of ERP components to complex memory processing. Brain Cogn. 1998; 36(3):355-76. DOI: 10.1006/brcg.1998.0998. View

19.

Dien J . Addressing misallocation of variance in principal components analysis of event-related potentials. Brain Topogr. 1998; 11(1):43-55. DOI: 10.1023/a:1022218503558. View

20.

WALTER W, Cooper R, ALDRIDGE V, MCCALLUM W, Winter A . CONTINGENT NEGATIVE VARIATION: AN ELECTRIC SIGN OF SENSORIMOTOR ASSOCIATION AND EXPECTANCY IN THE HUMAN BRAIN. Nature. 1964; 203:380-4. DOI: 10.1038/203380a0. View