Acyclic L-threoninol Nucleic Acid (L-aTNA) with Suitable Structural Rigidity Cross-pairs with DNA and RNA

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2015 Jan 31

PMID 25633432

Citations 9

Authors

Keiji Murayama

Hiromu Kashida

Hiroyuki Asanuma

Affiliations

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Abstract

We report the hybridization properties of a novel artificial nucleic acid: acyclic L-threoninol nucleic acid (L-aTNA). L-aTNA formed a more stable duplex with DNA and RNA than either D-aTNA or serinol nucleic acid (SNA) as the rigidity of the L-form was more optimal for interaction with natural nucleic acids.

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