Clinical Characteristics of Incidental or Unsuspected Gallbladder Cancers Diagnosed During or After Cholecystectomy: a Systematic Review and Meta-analysis

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2015 Jan 30

PMID 25632207

Citations 33

Authors

Kui Sun Choi

Sae Byeol Choi

Pyoungjae Park

Wan Bae Kim

Sang Yong Choi

Affiliations

Soon will be listed here.

Abstract

Aim: To perform a systematic review of incidental or unsuspected gallbladder (GB) cancer diagnosed during or after cholecystectomy.

Methods: Data in PubMed, EMBASE, and Cochrane Library were reviewed and 26 publications were included in the meta-analysis. The inclusion criterion for incidental GB cancer was GB cancer diagnosed during or after cholecystectomy that was not suspected at a preoperative stage. Pooled proportions of the incidence, distribution of T stage, and revisional surgery of incidental GB cancer were analyzed.

Results: The final pooled population comprised 2145 patients with incidental GB cancers. Incidental GB cancers were found in 0.7% of cholecystectomies performed for benign gallbladder diseases on preoperative diagnosis (95%CI: 0.004-0.012). Nearly 50% of the incidental GB cancers were stage T2 with a pooled proportion of 47.0% (95%CI: 0.421-0.519). T1 and T3 GB cancers were found at a similar frequency, with pooled proportions of 23.0% (95%CI: 0.178-0.291) and 25.1% (95%CI: 0.195-0.317), respectively. The pooled proportion that completed revisional surgery for curative intent was 40.9% (95%CI: 0.329-0.494). The proportion of patients with unresectable disease upon revisional surgery was 23.0% (95%CI: 0.177-0.294).

Conclusion: A large proportion of incidental GB cancers were T2 and T3 lesions. Revisional surgery for radical cholecystectomy is warranted in T2 and more advanced cancers.

Citing Articles

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Radical cholecystectomy without liver resection for peritoneal side early incidental gallbladder cancer.

Piccolo G, Barabino M, Piozzi G, Bianchi P World J Gastroenterol. 2024; 30(32):3739-3742.

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Late port-site metastasis of unexpected gallbladder carcinoma after laparoscopic cholecystectomy: A case report.

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