Synthesis and Characterization of Cerium- and Gallium-containing Borate Bioactive Glass Scaffolds for Bone Tissue Engineering

Overview

Journal J Mater Sci Mater Med

Publisher Springer

Specialty Biomedical Engineering

Date 2015 Jan 30

PMID 25631259

Citations 13

Authors

Aylin M Deliormanli

Affiliations

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Abstract

Bioactive glasses are widely used in biomedical applications due to their ability to bond to bone and even to soft tissues. In this study, borate based (13-93B3) bioactive glass powders containing up to 5 wt% Ce2O3 and Ga2O3 were prepared by the melt quench technique. Cerium (Ce+3) and gallium (Ga+3) were chosen because of their low toxicity associated with bacteriostatic properties. Bioactive glass scaffolds were fabricated using the polymer foam replication method. In vitro degradation and bioactivity of the scaffolds were evaluated in SBF under static conditions. Results revealed that the cerium- and gallium-containing borate glasses have much lower degradation rates compared to the bare borate glass 13-93B3. In spite of the increased chemical durability, substituted glasses exhibited a good in vitro bioactive response except when the Ce2O3 content was 5 wt%. Taking into account the high in vitro hydroxyapatite forming ability, borate glass scaffolds containing Ce+3 and Ga+3 therapeutic ions are promising candidates for bone tissue engineering applications.

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References

Hench L, Thompson I . Twenty-first century challenges for biomaterials. J R Soc Interface. 2010; 7 Suppl 4:S379-91. PMC: 2943892. DOI: 10.1098/rsif.2010.0151.focus. View

Huang W, Day D, Kittiratanapiboon K, Rahaman M . Kinetics and mechanisms of the conversion of silicate (45S5), borate, and borosilicate glasses to hydroxyapatite in dilute phosphate solutions. J Mater Sci Mater Med. 2006; 17(7):583-96. DOI: 10.1007/s10856-006-9220-z. View

Brink M, Turunen T, Happonen R, Yli-Urpo A . Compositional dependence of bioactivity of glasses in the system Na2O-K2O-MgO-CaO-B2O3-P2O5-SiO2. J Biomed Mater Res. 1997; 37(1):114-21. DOI: 10.1002/(sici)1097-4636(199710)37:1<114::aid-jbm14>3.0.co;2-g. View

Das S, Singh S, Dowding J, Oommen S, Kumar A, Sayle T . The induction of angiogenesis by cerium oxide nanoparticles through the modulation of oxygen in intracellular environments. Biomaterials. 2012; 33(31):7746-55. PMC: 4590782. DOI: 10.1016/j.biomaterials.2012.07.019. View

Collery P, Keppler B, Madoulet C, Desoize B . Gallium in cancer treatment. Crit Rev Oncol Hematol. 2002; 42(3):283-96. DOI: 10.1016/s1040-8428(01)00225-6. View

Fu Q, Rahaman M, Fu H, Liu X . Silicate, borosilicate, and borate bioactive glass scaffolds with controllable degradation rate for bone tissue engineering applications. I. Preparation and in vitro degradation. J Biomed Mater Res A. 2010; 95(1):164-71. DOI: 10.1002/jbm.a.32824. View

Verron E, Masson M, Khoshniat S, Duplomb L, Wittrant Y, Baudhuin M . Gallium modulates osteoclastic bone resorption in vitro without affecting osteoblasts. Br J Pharmacol. 2010; 159(8):1681-92. PMC: 2925491. DOI: 10.1111/j.1476-5381.2010.00665.x. View

Brown R, Rahaman M, Dwilewicz A, Huang W, Day D, Li Y . Effect of borate glass composition on its conversion to hydroxyapatite and on the proliferation of MC3T3-E1 cells. J Biomed Mater Res A. 2008; 88(2):392-400. DOI: 10.1002/jbm.a.31679. View

Kokubo T, Kushitani H, Sakka S, Kitsugi T, Yamamuro T . Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W. J Biomed Mater Res. 1990; 24(6):721-34. DOI: 10.1002/jbm.820240607. View

10.

Pickup D, Moss R, Qiu D, Newport R, Valappil S, Knowles J . Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses. J Chem Phys. 2009; 130(6):064708. DOI: 10.1063/1.3076057. View

11.

Jones J, Sepulveda P, Hench L . Dose-dependent behavior of bioactive glass dissolution. J Biomed Mater Res. 2001; 58(6):720-6. DOI: 10.1002/jbm.10053. View

12.

Franchini M, Lusvardi G, Malavasi G, Menabue L . Gallium-containing phospho-silicate glasses: synthesis and in vitro bioactivity. Mater Sci Eng C Mater Biol Appl. 2013; 32(6):1401-6. DOI: 10.1016/j.msec.2012.04.016. View

13.

Zhang X, Jia W, Gu Y, Xiao W, Liu X, Wang D . Teicoplanin-loaded borate bioactive glass implants for treating chronic bone infection in a rabbit tibia osteomyelitis model. Biomaterials. 2010; 31(22):5865-74. DOI: 10.1016/j.biomaterials.2010.04.005. View

14.

Jones J . Review of bioactive glass: from Hench to hybrids. Acta Biomater. 2012; 9(1):4457-86. DOI: 10.1016/j.actbio.2012.08.023. View

15.

Hench L . Bioactive materials: the potential for tissue regeneration. J Biomed Mater Res. 1998; 41(4):511-8. DOI: 10.1002/(sici)1097-4636(19980915)41:4<511::aid-jbm1>3.0.co;2-f. View

16.

Lu H, Pollack S, Ducheyne P . 45S5 bioactive glass surface charge variations and the formation of a surface calcium phosphate layer in a solution containing fibronectin. J Biomed Mater Res. 2001; 54(3):454-61. DOI: 10.1002/1097-4636(20010305)54:3<454::aid-jbm200>3.0.co;2-h. View

17.

Rahaman M, Day D, Bal B, Fu Q, Jung S, Bonewald L . Bioactive glass in tissue engineering. Acta Biomater. 2011; 7(6):2355-73. PMC: 3085647. DOI: 10.1016/j.actbio.2011.03.016. View

18.

Gu Y, Huang W, Rahaman M, Day D . Bone regeneration in rat calvarial defects implanted with fibrous scaffolds composed of a mixture of silicate and borate bioactive glasses. Acta Biomater. 2013; 9(11):9126-36. DOI: 10.1016/j.actbio.2013.06.039. View

19.

Warrell Jr R, Bockman R, Coonley C, Isaacs M, Staszewski H . Gallium nitrate inhibits calcium resorption from bone and is effective treatment for cancer-related hypercalcemia. J Clin Invest. 1984; 73(5):1487-90. PMC: 425172. DOI: 10.1172/JCI111353. View

20.

Jones J, Ehrenfried L, Saravanapavan P, Hench L . Controlling ion release from bioactive glass foam scaffolds with antibacterial properties. J Mater Sci Mater Med. 2006; 17(11):989-96. DOI: 10.1007/s10856-006-0434-x. View