Neuronal Differentiation of Adipose-derived Stem Cells and Their Transplantation for Cerebral Ischemia

Overview

Journal Neural Regen Res

Date 2015 Jan 28

PMID 25624830

Citations 6

Authors

Guoping Tian

Jin Zhou

Jinge Wang

Bing Xu

Li Li

Feng Zhu

Jian Han

Jianping Li

Siyang Zhang

Xiaoguang Luo

Affiliations

Soon will be listed here.

Abstract

Objective: To review published data on the biological characteristics, differentiation and applications of adipose-derived stem cells in ischemic diseases.

Data Retrieval: A computer-based online search of reports published from January 2005 to June 2012 related to the development of adipose-derived stem cells and their transplantation for treatment of cerebral ischemia was performed in Web of Science using the key words "adipose-derived stem cells", "neural-like cells", "transplantation", "stroke", and "cerebral ischemia".

Selection Criteria: The documents associated with the development of adipose-derived stem cells and their transplantation for treatment of cerebral ischemia were selected, and those published in the last 3-5 years or in authoritative journals were preferred in the same field. Totally 89 articles were obtained in the initial retrieval, of which 53 were chosen based on the inclusion criteria.

Main Outcome Measures: Biological characteristics and induced differentiation of adipose-derived stem cells and cell transplantation for disease treatment as well as the underlying mechanism of clinical application.

Results: The advantages of adipose-derived stem cells include their ease of procurement, wide availability, rapid expansion, low tumorigenesis, low immunogenicity, and absence of ethical constraints. Preclinical experiments have demonstrated that transplanted adipose-derived stem cells can improve neurological functions, reduce small regions of cerebral infarction, promote angiogenesis, and express neuron-specific markers. The improvement of neurological functions was demonstrated in experiments using different methods and time courses of adipose-derived stem cell transplantation, but the mechanisms remain unclear.

Conclusion: Further research into the treatment of ischemic disease by adipose-derived stem cell transplantation is needed to determine their mechanism of action.

Citing Articles

An update on stem cell and stem cell-derived extracellular vesicle-based therapy in the management of Alzheimer's disease.

Jeyaraman M, Rajendran R, Muthu S, Jeyaraman N, Sharma S, Jha S Heliyon. 2023; 9(7):e17808.

PMID: 37449130 PMC: 10336689. DOI: 10.1016/j.heliyon.2023.e17808.

Advances in stromal cell therapy for management of Alzheimer's disease.

Srivastava R, Li A, Datta T, Jha N, Talukder S, Jha S Front Pharmacol. 2022; 13:955401.

PMID: 36267273 PMC: 9576849. DOI: 10.3389/fphar.2022.955401.

Neurogenic and Neuroprotective Potential of Stem/Stromal Cells Derived from Adipose Tissue.

Figiel-Dabrowska A, Radoszkiewicz K, Rybkowska P, Krzesniak N, Sulejczak D, Sarnowska A Cells. 2021; 10(6).

PMID: 34208414 PMC: 8231154. DOI: 10.3390/cells10061475.

Characteristics and Potentiality of Human Adipose-Derived Stem Cells (hASCs) Obtained from Enzymatic Digestion of Fat Graft.

Gentile P, Piccinno M, Calabrese C Cells. 2019; 8(3).

PMID: 30934588 PMC: 6469026. DOI: 10.3390/cells8030282.

Intravenous Administration of Adipose-Derived Stem Cell Protein Extracts Improves Neurological Deficits in a Rat Model of Stroke.

Zhao K, Li R, Gu C, Liu L, Jia Y, Guo X Stem Cells Int. 2017; 2017:2153629.

PMID: 28265288 PMC: 5318632. DOI: 10.1155/2017/2153629.

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