Inhibition of PAD4 Activity is Sufficient to Disrupt Mouse and Human NET Formation

Overview

Journal Nat Chem Biol

Specialties Biochemistry
Biology
Chemistry

Date 2015 Jan 27

PMID 25622091

Citations 345

Authors

Huw D Lewis

John Liddle

Jim E Coote

Stephen J Atkinson

Michael D Barker

Benjamin D Bax

Kevin L Bicker

Ryan P Bingham

Matthew Campbell

Yu Hua Chen

Chun-Wa Chung

Peter D Craggs

Rob P Davis

Dirk Eberhard

Gerard Joberty

Kenneth E Lind

Kelly Locke

Claire Maller

Kimberly Martinod

Chris Patten

Oxana Polyakova

Cecil E Rise

Martin Rudiger

Robert J Sheppard

Daniel J Slade

Pamela Thomas

Jim Thorpe

Gang Yao

Gerard Drewes

Denisa D Wagner

Paul R Thompson

Rab K Prinjha

David M Wilson

Affiliations

Soon will be listed here.

Abstract

PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases through clinical genetics and gene disruption in mice. New selective PAD4 inhibitors binding a calcium-deficient form of the PAD4 enzyme have validated the critical enzymatic role of human and mouse PAD4 in both histone citrullination and neutrophil extracellular trap formation for, to our knowledge, the first time. The therapeutic potential of PAD4 inhibitors can now be explored.

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