Membrane Curvature Enables N-Ras Lipid Anchor Sorting to Liquid-ordered Membrane Phases

Overview

Journal Nat Chem Biol

Specialties Biochemistry
Biology
Chemistry

Date 2015 Jan 27

PMID 25622090

Citations 57

Authors

Jannik Bruun Larsen

Martin Borch Jensen

Vikram K Bhatia

Soren L Pedersen

Thomas Bjornholm

Lars Iversen

Mark Uline

Igal Szleifer

Knud J Jensen

Nikos S Hatzakis

Dimitrios Stamou

Affiliations

Soon will be listed here.

Abstract

Trafficking and sorting of membrane-anchored Ras GTPases are regulated by partitioning between distinct membrane domains. Here, in vitro experiments and microscopic molecular theory reveal membrane curvature as a new modulator of N-Ras lipid anchor and palmitoyl chain partitioning. Membrane curvature was essential for enrichment in raft-like liquid-ordered phases; enrichment was driven by relief of lateral pressure upon anchor insertion and most likely affects the localization of lipidated proteins in general.

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