Neonatal Brain Hemorrhage (NBH) of Prematurity: Translational Mechanisms of the Vascular-neural Network

Overview

Journal Curr Med Chem

Publisher Bentham Science Publishers

Specialty Chemistry

Date 2015 Jan 27

PMID 25620100

Citations 20

Authors

Tim Lekic

Damon Klebe

Roy Poblete

Paul R Krafft

William B Rolland

Jiping Tang

John H Zhang

Affiliations

Soon will be listed here.

Abstract

Neonatal brain hemorrhage (NBH) of prematurity is an unfortunate consequence of preterm birth. Complications result in shunt dependence and long-term structural changes such as posthemorrhagic hydrocephalus, periventricular leukomalacia, gliosis, and neurological dysfunction. Several animal models are available to study this condition, and many basic mechanisms, etiological factors, and outcome consequences, are becoming understood. NBH is an important clinical condition, of which treatment may potentially circumvent shunt complication, and improve functional recovery (cerebral palsy, and cognitive impairments). This review highlights key pathophysiological findings of the neonatal vascular-neural network in the context of molecular mechanisms targeting the posthemorrhagic hydrocephalus affecting this vulnerable infant population.

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