Towards Co-evolution of Membrane Proteins and Metabolism
Overview
Molecular Biology
Affiliations
Primordial metabolism co-evolved with the earliest membrane peptides to produce more environmentally fit progeny. Here, we map a continuous, evolutionary path that connects nascent biochemistry with simple, membrane-bound oligopeptides, ion channels and, further, membrane proteins capable of energy transduction and utilization of energy for active transport.
Elucidating N-acyl amino acids as a model protoamphiphilic system.
Joshi M, Uday A, Rajamani S Commun Chem. 2023; 5(1):147.
PMID: 36697941 PMC: 9814278. DOI: 10.1038/s42004-022-00762-9.
Systems protobiology: origin of life in lipid catalytic networks.
Lancet D, Zidovetzki R, Markovitch O J R Soc Interface. 2018; 15(144).
PMID: 30045888 PMC: 6073634. DOI: 10.1098/rsif.2018.0159.
Wieczorek R, Adamala K, Gasperi T, Polticelli F, Stano P Life (Basel). 2017; 7(2).
PMID: 28397774 PMC: 5492141. DOI: 10.3390/life7020019.
Emergence of Life on Earth: A Physicochemical Jigsaw Puzzle.
Spitzer J J Mol Evol. 2016; 84(1):1-7.
PMID: 27995274 DOI: 10.1007/s00239-016-9775-3.
Liu Z, Rigger L, Rossi J, Sutherland J, Pascal R Chemistry. 2016; 22(42):14940-14949.
PMID: 27534830 PMC: 5074369. DOI: 10.1002/chem.201602697.