Evidence of Nicotine-Induced, Curare-Insensitive, Behavior in Planarians

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 2015 Jan 24

PMID 25614180

Citations 5

Authors

One R Pagan

Erica Montgomery

Sean Deats

Daniel Bach

Debra Baker

Affiliations

Soon will be listed here.

Abstract

Planarians are rapidly developing into very useful research subjects in pharmacology and neuroscience research. Here we report that curare, a cholinergic nicotinic receptor antagonist, alleviates the nicotine-induced planarian seizure-like movements (pSLM) by up to 50 % at equimolar concentrations of nicotine and curare (1 mM), while curare alone does not induce significant pSLMs. The simplest interpretation of our data is that there are nicotine induced behaviors insensitive to curare in our experimental organism. To the best of our knowledge, this is the first report on curare-insensitive, nicotine-induced effects in any organism.

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