Characterization of Co-purified Acellular Pertussis Vaccines

Overview

Journal Hum Vaccin Immunother

Specialty Allergy & Immunology

Date 2015 Jan 23

PMID 25610957

Citations 15

Authors

Yinghua Xu

Yajun Tan

Catpagavalli Asokanathan

Shumin Zhang

Dorothy Xing

Junzhi Wang

Affiliations

Soon will be listed here.

Abstract

Whole-cell pertussis vaccines (WPVs) have been completely replaced by the co-purified acellular vaccines (APVs) in China. To date few laboratory studies were reported for co-purified APVs in terms of their antigenic composition and protective immune responses. To further understand the antigenic composition in co-purified APVs, in the present study 2-dimensional gel electrophoresis-based proteomic technology was used to analyze the composition of co-purified APVs. The results showed that besides the main antigens pertussis toxin (PT) and filamentous hemagglutinin (FHA), co-purified APVs also contained pertactin (PRN), fimbriae (FIM) 2and3 and other minor protein antigens. Of the 9 proteins identified, 3 were differentially presented in products from manufacturer 1 and manufacturer 2. Compared with WPVs and purified APVs, co-purified APVs induced a mixed Th1/Th2 immune response with more toward to a Th1 response than the purified APVs in this study. These results hint that different immune mechanisms might be involved in protection induced by co-purified and purified APVs.

Citing Articles

Molecular characterization and antimicrobial susceptibility for 62 isolates of from children.

He B, Jia Z, Zheng F, Zhang W, Duan S, Wang L Front Microbiol. 2024; 15:1498638.

PMID: 39723144 PMC: 11668733. DOI: 10.3389/fmicb.2024.1498638.

Seroepidemiology of pertussis immunity in five provinces of China: A population-based, cross-sectional study.

Zhang Z, Wang Q, Zhu Q, Bai S, Liu Y, Ren J Hum Vaccin Immunother. 2024; 20(1):2417532.

PMID: 39544177 PMC: 11572084. DOI: 10.1080/21645515.2024.2417532.

Post-COVID-19 pandemic changes in pertussis incidence among patients with acute respiratory tract infections in Zhejiang, China.

Wang H, Fu M, Chen W, Ma Y Front Microbiol. 2024; 15:1448997.

PMID: 39184026 PMC: 11342075. DOI: 10.3389/fmicb.2024.1448997.

Development and validation of enzyme-linked immunosorbent assay for anti-mouse pertussis immunoglobulin G using international reference anti- mouse serum NIBSC 97/642.

Kang K, Kwon Y, Cho G, Choi G, Ji J, Kang H Clin Exp Vaccine Res. 2024; 13(3):242-252.

PMID: 39144122 PMC: 11319115. DOI: 10.7774/cevr.2024.13.3.242.

Comparing the pertussis antibody levels of healthy children immunized with four doses of DTap-IPV/Hib (Pentaxim) combination vaccine and DTaP vaccine in Quzhou, China.

Yin Z, Zheng C, Fang Q, Wen T, Wang S, Li J Front Immunol. 2023; 13:1055677.

PMID: 36685526 PMC: 9852981. DOI: 10.3389/fimmu.2022.1055677.

References

Zhu F . Pertussis booster vaccine in China. Hum Vaccin. 2011; 7(2):272-5. DOI: 10.4161/hv.7.2.13861. View

Fisman D, Tang P, Hauck T, Richardson S, Drews S, Low D . Pertussis resurgence in Toronto, Canada: a population-based study including test-incidence feedback modeling. BMC Public Health. 2011; 11:694. PMC: 3189138. DOI: 10.1186/1471-2458-11-694. View

Coleman M, Finlay C, Moran B, Keane J, Dunne P, Mills K . The immunoregulatory role of CD4⁺ FoxP3⁺ CD25⁻ regulatory T cells in lungs of mice infected with Bordetella pertussis. FEMS Immunol Med Microbiol. 2012; 64(3):413-24. DOI: 10.1111/j.1574-695X.2011.00927.x. View

Cherry J . Why do pertussis vaccines fail?. Pediatrics. 2012; 129(5):968-70. DOI: 10.1542/peds.2011-2594. View

Kmietowicz Z . Pertussis cases rise 10-fold among older children and adults in England and Wales. BMJ. 2012; 345:e5008. DOI: 10.1136/bmj.e5008. View

Klein N, Bartlett J, Rowhani-Rahbar A, Fireman B, Baxter R . Waning protection after fifth dose of acellular pertussis vaccine in children. N Engl J Med. 2012; 367(11):1012-9. DOI: 10.1056/NEJMoa1200850. View

Poland G . Pertussis outbreaks and pertussis vaccines: new insights, new concerns, new recommendations?. Vaccine. 2012; 30(49):6957-9. DOI: 10.1016/j.vaccine.2012.09.084. View

Witt M, Arias L, Katz P, Truong E, Witt D . Reduced risk of pertussis among persons ever vaccinated with whole cell pertussis vaccine compared to recipients of acellular pertussis vaccines in a large US cohort. Clin Infect Dis. 2013; 56(9):1248-54. DOI: 10.1093/cid/cit046. View

Ross P, Sutton C, Higgins S, Allen A, Walsh K, Misiak A . Relative contribution of Th1 and Th17 cells in adaptive immunity to Bordetella pertussis: towards the rational design of an improved acellular pertussis vaccine. PLoS Pathog. 2013; 9(4):e1003264. PMC: 3617212. DOI: 10.1371/journal.ppat.1003264. View

10.

Wang L, Lei D, Zhang S . Acellular pertussis vaccines in China. Vaccine. 2012; 30(50):7174-8. DOI: 10.1016/j.vaccine.2012.10.009. View

11.

Horiuchi Y, Takahashi M, Konda T, Ochiai M, Yamamoto A, Kataoka M . Quality control of diphtheria tetanus acellular pertussis combined (DTaP) vaccines in Japan. Jpn J Infect Dis. 2001; 54(5):167-80. View

12.

Fuchslocher B, Millar L, Cotter P . Comparison of bipA alleles within and across Bordetella species. Infect Immun. 2003; 71(6):3043-52. PMC: 155730. DOI: 10.1128/IAI.71.6.3043-3052.2003. View

13.

Gardy J, Spencer C, Wang K, Ester M, Tusnady G, Simon I . PSORT-B: Improving protein subcellular localization prediction for Gram-negative bacteria. Nucleic Acids Res. 2003; 31(13):3613-7. PMC: 169008. DOI: 10.1093/nar/gkg602. View

14.

Church M . Evidence of whooping-cough-vaccine efficacy from the 1978 whooping-cough epidemic in Hertfordshire. Lancet. 1979; 2(8135):188-90. DOI: 10.1016/s0140-6736(79)91447-8. View

15.

. Efficacy of pertussis vaccination in England. Report from the PHLS Epidemiological Research Laboratory and 21 area health authorities. Br Med J (Clin Res Ed). 1982; 285(6338):357-9. PMC: 1499024. DOI: 10.1136/bmj.285.6338.357. View

16.

Sato Y, Kimura M, FUKUMI H . Development of a pertussis component vaccine in Japan. Lancet. 1984; 1(8369):122-6. DOI: 10.1016/s0140-6736(84)90061-8. View

17.

STEWART G . Whooping cough and pertussis vaccine: a comparison of risks and benefits in Britain during the period 1968-83. Dev Biol Stand. 1985; 61:395-405. View

18.

Redhead K, Watkins J, Barnard A, Mills K . Effective immunization against Bordetella pertussis respiratory infection in mice is dependent on induction of cell-mediated immunity. Infect Immun. 1993; 61(8):3190-8. PMC: 280987. DOI: 10.1128/iai.61.8.3190-3198.1993. View

19.

Barnard A, Mahon B, Watkins J, Redhead K, Mills K . Th1/Th2 cell dichotomy in acquired immunity to Bordetella pertussis: variables in the in vivo priming and in vitro cytokine detection techniques affect the classification of T-cell subsets as Th1, Th2 or Th0. Immunology. 1996; 87(3):372-80. PMC: 1384104. DOI: 10.1046/j.1365-2567.1996.497560.x. View

20.

Ausiello C, Urbani F, la Sala A, Lande R, Cassone A . Vaccine- and antigen-dependent type 1 and type 2 cytokine induction after primary vaccination of infants with whole-cell or acellular pertussis vaccines. Infect Immun. 1997; 65(6):2168-74. PMC: 175299. DOI: 10.1128/iai.65.6.2168-2174.1997. View